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TB Diagnostics at the Point of Care

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43MD008597-01
Agency Tracking Number: R43MD008597
Amount: $396,601.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIMHD
Solicitation Number: EB12-001
Solicitation Year: 2013
Award Year: 2013
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
56 Quarry Rd
TRUMBULL, CT 06611-4874
United States
DUNS: 830264383
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (978) 604-1246
Business Contact
Phone: (978) 604-1246
Research Institution

DESCRIPTION (provided by applicant): Persistent pain is the number one reason that patients access the healthcare system according to the National institutes of Health. Pain seriously affects patients' quality of life and is associated with secondary morbidities such as depression, anxiety, and sleep disturbance. Medications are often the first-line treatment for pain relief, but they are not without serious side effects. Particularly for rural citizens and socioeconomic disadvantaged individuals very few non-pharmacotherapy regimes exist to help manage pain. Ultrasound has been used safely and effectively for years to provide pain relief. Additionally, the mechanical and thermal mechanisms of action in ultrasound have been shown to facilitate wound and bonefracture healing, to promote the penetration of topical ointments into the skin and found to enhance a variety healthcare applications. Despite the potential of ultrasound therapy, the size, price, and mode of delivery has prohibited its broad translation. We have developed a new ultrasound device that provides a unique platform solution for ultrasound in frontline medicine in disparate and socioeconomic disadvantaged communities. The system relies on aggressive miniaturization and integration of the ultrasound transducer, electronics, and power supply to produce an iPod- sized low-intensity ultrasound system that can deliver portable, convenient, and effective therapy for long durations. For this project, the iPod-sized ultrasound devices will be refined and clinically evaluated on subjects with osteoarthritis of the knee. Subjects will be asked to wear the device for 6 hours a day over the duration of the study, and will be monitored for reductions in pain, increased mobility and their use of pharmaceuticals for pain control. Successful completion of the study will increase scientific understanding of the efficacy of low- intensity continuous ultrasound treatment on musculoskeletal pain and mobility from OA, and provide the first non-invasive, portable, transformative solution to pain control. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: The proposed work is relevant to the treatment and management of osteoarthritis (OA) and chronic pain. Over 46 million people in the United States have limited mobility and pain because of OA. Here, a new non-invasive wearable therapeutic ultrasound device will be evaluated clinically, as a pharmaceutical free approach to OA management.

* Information listed above is at the time of submission. *

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