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A Self-Contained Assay Device for Rapid Detection of Viable Cryptosporidium in Wa

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43AI110017-01
Agency Tracking Number: R43AI110017
Amount: $142,383.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIAID
Solicitation Number: PA13-088
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
535 W Research Blvd., Suite 135, M/S 300
FAYETTEVILLE, AR 72701-6922
United States
DUNS: 125476825
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 XIAOLI SU
 (479) 571-2592
 xiaoli.su@biodetection-instruments.
Business Contact
 JOHN CHAMBERLIN
Phone: (479) 571-2592
Email: john.chamberlin@biodetection-instru
Research Institution
 Stub
Abstract

DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project will investigate the technical feasibility of an in vitro excystation-based automated cartridge assay for rapid detection of viable Cryptosporidium oocysts in water. Briefly, viable oocysts will be subjected to an in vitro excystation step to release sporozoites and the antigens for detection on a patent-pending self- contained cartridge immunoassay system. The Phase I research will focus on demonstrating the feasibility of specific detection of viable oocysts with a direct detection limit (i.e., without sample preconcentration) of d100-1000 oocysts/mL within in 1-2 h, which will be improved in Phase II to achieve the detection of d100 oocysts/10 L with sample preconcentration. The proposed assay will ultimately be highly automated and provide quantitative results for viable oocysts within 4 h from sample acquisition, largely reducing the complexity and lengthiness of current standard methods and allowing for ne

* Information listed above is at the time of submission. *

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