You are here

Real-time assessment of surgical margins with enhanced contract optical imaging

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43CA173998-01A1
Agency Tracking Number: R43CA173998
Amount: $224,999.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NCI
Solicitation Number: PA13-088
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
20 New England Business Center
Andover, MA 01810-1077
United States
DUNS: 73800062
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (978) 689-0003
Business Contact
Phone: (978) 689-0003
Research Institution

DESCRIPTION (provided by applicant): Physical Sciences, Inc. (PSI), in collaboration with Massachusetts General Hospital proposes to investigate the use of a high sensitivity/specificity cancer targeting agent and of a novel fluorescence-guided microscopy(FGM) scheme for intraoperative assessment of surgical margins in breast cancer patients. The contrast agent will be used to label cancer cells and highlight positive margins on lumpectomy specimens. FGM will then be used to visualize tissue morphology atthe cellular scale and provide the pathologist with histology-like images to confirm or rule out cancer presence. In Phase I we propose to develop, test, and optimize a suitable contrast agent for cancer labeling and a benchtop instrument that will combinefluorescence imaging and high resolution/penetration depth coherence microscopy within the same optical platform with automated dual modal image registration. Preliminary testing of this technology will be performed on several surgical specimens. Based on

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government