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Develop extremely-high-yield (5-10x conventional methods) tissue microarray techn

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43CA183180-01
Agency Tracking Number: R43CA183180
Amount: $224,303.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NCI
Solicitation Number: PA13-088
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
475 GATE 5 RD, STE 215
SAUSALITO, CA 94965-2833
United States
DUNS: 832363738
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 WILLIAM CRAWFORD
 (415) 944-9724
 crawford@arrayscience.com
Business Contact
 WILLIAM CRAWFORD
Phone: (650) 575-8329
Email: crawford@arrayscience.com
Research Institution
 Stub
Abstract

DESCRIPTION (provided by applicant): We (Array Science, LLC) propose to perform detailed research and development of our patent-pending method and instrument for high-yield production of tissue microarrays (TMAs). Our approach to TMA production is novel inleveraging the liquid phase of standard histologic embedding media such as paraffin, and in so doing we achieve unprecedented levels of utilization of precious biological tissue sources. The outcome of this technique has proven highly beneficial in cancerdiagnostics, where it has produced over 1.3 million TMA sections for on-slide controls in a major immunohistochemistry (IHC) laboratory, and in IHC proficiency testing, where we have achieved new levels of yield as a supplier to the College of American Pathologists. Whereas conventional TMA production methods yield 100-300 slides per TMA block, our method routinely produces 1500 slides per TMA block, with highly reduced levels of waste of source tissue. Theoretical yield is still up to twice our curre

* Information listed above is at the time of submission. *

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