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Development of a matrix-based platform for the collection and storage of nucleic

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43HG007785-01
Agency Tracking Number: R43HG007785
Amount: $205,804.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NHGRI
Solicitation Number: PAR13-203
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
2500 FABER PLACE
PALO ALTO, CA 94303-3329
United States
DUNS: 606829013
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 JAMES WINGROVE
 (650) 475-2706
 jwingrove@cardiodx.com
Business Contact
 JAMES WINGROVE
Phone: (650) 475-2706
Email: jwingrove@cardiodx.com
Research Institution
 Stub
Abstract

DESCRIPTION (provided by applicant): Current tube-based methods for collecting whole blood RNA such as PAXgeneTM have a number of limitations including need for access to phlebotomy, temperature controlled transport, and relatively large volumes of whole blood. No solid-matrix based methods for obtaining RNA from whole blood currently exist. Our goal is the development and implementation of a solid, matrix-based approach for obtaining and stabilizing both RNA and DNA from whole blood, which would address these limitations. In conjunction with investigators at General Electric, we have prototyped an initial platform, term RNA Stabilization Matrix (RSM). In the current proposal we plan to expand upon our initial work in four areas: (1) We plan to develop automated methods using liquid handling robotics for extracting RNA from RSM; such methods will increase throughput as well as decrease variability associated with manual processing. (2) We plan to develop methods allowing for whole transcriptome analysi

* Information listed above is at the time of submission. *

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