You are here

Novel Small Molecule Therapeutics for Pancreatic Cancer

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41CA176931-01A1
Agency Tracking Number: R41CA176931
Amount: $240,555.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NCI
Solicitation Number: PA13-089
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
11171 CORTE CANGREJO
SAN DIEGO, CA 92130-2637
United States
DUNS: 831483388
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 KARL OKOLOTOWICZ
 (858) 458-9307
 kokolotowicz@hbri.org
Business Contact
 REBEKAH HANDLEY
Phone: (858) 458-9307
Email: rhandley@chemregen.com
Research Institution
 HUMAN BIOMOLECULAR RESEARCH INSTITUTE
 
HUMAN BIOMOLECULAR RESEARCH INST 5310 EASTGATE MALL
SAN DIEGO, CA 92121-2804
United States

 () -
 Domestic Nonprofit Research Organization
Abstract

Project Summary/Abstract Developing new ways to treat pancreatic cancer is a significant challenge. Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States and results in an estimated 37,000 deaths/year. Pancreatic cancer therapeutic options are limited to surgery and/or combinations of chemotherapy and radiation. Unfortunately, late-stage diagnosis of pancreatic cancer renders current therapies ineffective. The effectiveness of relatively new targeted treatments remainsto be shown. There is an urgent major unmet medical need for the development of selective treatments for pancreatic cancer. Our new approach to pancreatic cancer is completely different and focuses on inhibition of a key molecular pathway. We have discovered and optimized a small molecule (i.e., 2) that selectively and potently inhibits a key molecular pathway. The overall Goal is to test this novel small molecule as an inhibitor to suppress pancreatic cancer progression by targeting a key signaling path

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government