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Enable Early and Sensitive In Vivo Detection of Liver Metastasis by Protein-based

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41CA183376-01A1
Agency Tracking Number: R41CA183376
Amount: $225,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NCI
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
5075 LAKE FJORD PASS
MARIETTA, GA 30068-1641
United States
DUNS: 78419511
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 JENNY YANG
 (404) 413-5520
 inlightabiosciencesllc@gmail.com
Business Contact
 JIE YANG
Phone: (404) 429-1434
Email: inlightabiosciencesllc@gmail.com
Research Institution
 GEORGIA STATE UNIVERSITY
 
GEORGIA STATE UNIVERSITY PO BOX 3999
ATLANTA, GA 30302-3999
United States

 () -
 Nonprofit College or University
Abstract

DESCRIPTION (provided by applicant): The major barriers limiting the application of MRI to detect small liver lesions and metastasis at the early stage and patient selection for targeted therapy based on molecular imaging of disease biomarkers, are due tothe lack of desired MRI contrast agents capable of enhancing the contrast between normal liver tissues and tumors with high relaxivity, tumor targeting, high intra-tumoral distribution and no toxicity. The low sensitivty related to low relaxivity of the current clinically approved contrast agents has posted additional limitations to the further application of MRI to monitor the effect of metastasis treatment, including image-guided laser ablation. To address the critical need, We (Dr. Jenny J. Yang's team in Atlanta) have developed a novel class of protein-based MRI contrast agents which exhibit significant improvement of both r1 and r2 relaxivities compared to the clinical MRI contrast agents, an improvement in in vivo dose efficiency in mouse models,

* Information listed above is at the time of submission. *

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