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Mitochondrial Uncoupling as a Therapeutic Target in Obesity

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41DK097862-01A1
Agency Tracking Number: R41DK097862
Amount: $183,070.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIDDK
Solicitation Number: PA13-089
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
GEORGETOWN, KY 40324-8040
United States
DUNS: 171691988
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (859) 323-4684
Business Contact
Phone: (859) 361-5678
Research Institution
LEXINGTON, KY 40506-0057
United States

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 Nonprofit college or university

DESCRIPTION (provided by applicant): Obesity is recognized as a national and global epidemic, as approximately 65% of adults in the United States are classified as overweight or obese as defined by body mass index (BMI). In fact, in the year 2000, the human race reached a historical landmark, when for the first time in history the number of adults with excess weight surpassed the number of those who were underweight. Obesity is linked with several cardiovascular risk factors cumulatively recognized as the metabolic syndrome. While obesity is associated with increased risk for metabolic syndrome and cardiovascular disease; consequently, weight loss in obese subjects has been demonstrated to reduce or reverse health risk factors. Fundamentally, irrespective ofthe method by which weight loss occurs, even a modest reduction in body weight has been shown to consistently reduce or reverse risk factors. In the 1930s it was recognized that increasing the body's basal metabolism using mitochondrial uncouplers, d

* Information listed above is at the time of submission. *

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