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Hepatitis C Virus RNA-Targeted Therapeutics

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41AI108104-01A1
Agency Tracking Number: R41AI108104
Amount: $149,156.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIAID
Solicitation Number: PA12-091
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1290 W 2320 S, STE E
SALT LAKE CITY, UT 84119-1476
United States
DUNS: 46301945
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 ASHOK BAJJI
 (801) 212-9801
 ashok.bajji@viogenbio.com
Business Contact
 ASHOK BAJJI
Phone: (801) 212-9801
Email: ashok.bajji@viogenbio.com
Research Institution
 UNIVERSITY OF UTAH
 
UNIVERSITY OF UTAH 75 South 2000 East Room 111
SALT LAKE CITY, UT 84112-8930
United States

 () -
 Nonprofit College or University
Abstract

DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) infection is a significant human health issue, accounting for 50% of liver transplants in the US, with approximately 170 million persons infected worldwide. The current standard of care therapy of PEGylated-interferon and ribavirin is effective in only about 50% of patients, with severe side effects and contraindications limiting patient compliance. New therapeutics targeting HCV protease have recently been approved, and additional therapies targeted the HCV NS5B RNA polymerase and the HCV NS5A accessory protein are in clinical trials. With each of these new therapies however, drug resistance is known to develop, and those new therapies have shown significant side effects. The experience with HIV therapy suggests that a truly effective regimen against HCV will consist of a cocktail of drugs against several HCV targets. HCV protein synthesis is initiated from the uncapped (+)strand RNA genome, utilizing a novel RNA structure in the 5'-untranslat

* Information listed above is at the time of submission. *

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