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Testing Smad7-based biologics for treating chronic wounds

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41AR067106-01
Agency Tracking Number: R41AR067106
Amount: $194,672.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIAMS
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
12635 E MONTVIEW BLVD
AURORA, CO 80045-7335
United States
DUNS: 783743938
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 XIAO-JING WANG
 (303) 724-3001
 xiao-jing@taigabiotech.com
Business Contact
 BRIAN TURNER
Phone: (303) 949-2890
Email: turner@taigabiotech.com
Research Institution
 UNIVERSITY OF COLORADO DENVER
 
UNIVERSITY OF COLORADO DENVER GRANTS AND CONTRACTS, MAIL STOP F428 ANSCHUTZ MEDICAL CAMPUS, BLDG 500 13001 E 1
AURORA, CO 80045-2570
United States

 () -
 Nonprofit College or University
Abstract

DESCRIPTION (provided by applicant): Chronic skin wounds associated with various diseases (e.g., diabetes) and aberrant healing from acute wounding (e.g., hypertrophic scarring) is a major health care burden, which need scientific discovery-based therapeutic interventions. Our previous studies show that Smad7, a TGFb signaling antagonist, accelerates skin wound healing. We have developed a Smad7 fusion protein that contains the human Smad7 fused to the HIV-1 Tat protein transduction domain (PTD). The Tat-Smad7 protein can rapidly penetrate cells upon contact. Our preliminary data revealed that topical Tat-Smad7 application to skin wounds accelerated healing in wildtype and diabetes (db/db) mice. Our preliminary data also suggest that the Tat fusion protein containing either the N-terminal 258aa of Smad7 (Tat-N-Smad7) or the C-terminal 259-426aa of Smad7 (Tat-C-Smad7) could have full or partial effects of Tat-Smad7. This Phase I STTR application proposes to compare fusion protein efficacies of full length

* Information listed above is at the time of submission. *

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