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Lateral Flow Immunoassays For Pharmacokinetic Dosing Of Monoclonal Antibodies

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41CA192697-01
Agency Tracking Number: R41CA192697
Amount: $222,135.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NCI
Solicitation Number: PA14-072
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
5448 Pire Ave
San Diego, CA 92122-4126
United States
DUNS: 68800915
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 BRADLEY MESSMER
 (858) 534-1783
 messmeb@gmail.com
Business Contact
 BRADLEY MESSMER
Phone: (858) 248-9253
Email: messmeb@gmail.com
Research Institution
 UNIVERSITY OF CALIFORNIA SAN DIEGO
 
UNIVERSITY OF CALIFORNIA SAN DIEGO 9500 GILMAN DR, DEPT 0934
LA JOLLA, CA 92093-0934
United States

 () -
 Nonprofit College or University
Abstract

DESCRIPTION (provided by applicant): Monoclonal antibodies (mAb) are used to treat a variety of cancers and other diseases. Dosing is typically based on body surface area, but population pharmacokinetic (PK) data suggests considerable variation across patients. Furthermore, there is growing evidence that patients with low final trough levels of circulating antibody have a poorer outcome, suggesting that dynamic monitoring of blood antibody levels and treating until a defined threshold is obtained may improve outcomes. Similar pharmacokinetic dosing has greatly improved some chemotherapy agents. We have previously developed laboratory assays for the quantitation of mAb in treated patients and lateral flow immunoassays (LFA) for counterfeit detection using mimetope peptides that specifically bind to a given mAb. For this project, we propose to develop prototype LFA devices that can determine if a given mAb is present in a blood sample above a predefined threshold concentration (CT). Devices will be produce

* Information listed above is at the time of submission. *

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