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Preclinical Efficacy of Silicon-based Dual Energy CT Contrast Material

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41DK104580-01
Agency Tracking Number: R41DK104580
Amount: $233,351.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIDDK
Solicitation Number: PA14-072
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
780 CLYDESDALE DR
HILLSBOROUGH, CA 94010-7408
United States
DUNS: 79125772
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 DONG-WEI GAO
 (415) 680-5204
 dongweigao2013@gmail.com
Business Contact
 BENJAMIN YEH
Phone: (415) 680-5204
Email: benjamin.yeh@gmail.com
Research Institution
 UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
 
UNIVERSITY OF CALIFORNIA SAN FRANCISCO 3333 California Street., Ste 315
SAN FRANCISCO, CA 94143-0962
United States

 () -
 Nonprofit College or University
Abstract

DESCRIPTION (provided by applicant): Our long term goal is to revolutionize the safety and effectiveness of computed tomography (CT) imaging for millions of Americans across a broad range of gastrointestinal disease. Bowel and intravenous contrast materials improve the CT imaging of abdominal disease. Unfortunately, none of the current clinical contrast materials are visibly different from the others at imaging, even on modern dual energy CT (DECT) scanners, because all agents are based on iodine or bariumwhich attenuate X-rays similarly across different X-ray spectra. This limitation leads to ambiguous images that cost over 2B in medical errors annually in the USA. We now have dramatic preclinical in vivo data showing that novel oral silicone materials can be delivered concurrently with yet be easily differentiated from current iodinated intravenous agents to produce simultaneous, high-resolution, perfectly co-registered CT images of the bowel and vasculature in a single pass of the DECT scanner. Such

* Information listed above is at the time of submission. *

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