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Disposable paper-based electrochemical metal ion sensors for water safety testing

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41ES024626-01
Agency Tracking Number: R41ES024626
Amount: $222,639.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIEHS
Solicitation Number: PA13-235
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
MCLEAN, VA 22102-1602
United States
DUNS: 962122052
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: Yes
Principal Investigator
 (402) 472-5340
Business Contact
Phone: (703) 375-9267
Research Institution
151 Whittier Research Center 2200 Vine Street
LINCOLN, NE 68583-0861
United States

 () -
 Nonprofit College or University

DESCRIPTION (provided by applicant): This Phase I application aims at developing a generalizable electrochemical biosensing platform for detection of metal ions in water. Specifically, the main objective of the project is to validate the design of a convenient, cost-effective electrochemical ion (E-ION) sensing platform for direct detection of metal ion contaminants such as mercury (Hg2+), silver (Ag+), and copper (Cu2+) in drinking water. While previously developed metal ions sensors have been demonstratedto possess exceptional sensitivity and selectivity, no generalizable sensor architecture that is applicable to the detectin of a wide range of metal ions has been realized to date. The E- ION sensor's signaling mechanism relies on the dampening of the DNArecognition probe dynamics upon target binding which involves inter-strand metal complexation, thereby creating a sensor that is inherently signal-off when interrogated using alternating current voltammetry. However, by varying the applied frequenc

* Information listed above is at the time of submission. *

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