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High-Purity Peptide Libraries without Chromatographic Separation

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41ES025294-01
Agency Tracking Number: R41ES025294
Amount: $225,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIEHS
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
9 BAILEY ST
SOMERVILLE, MA 02144-1215
United States
DUNS: 78757935
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 KRISHNA KUMAR
 (617) 627-5651
 krishna.kumar@tufts.edu
Business Contact
 VIJAY K
Phone: (617) 475-0981
Email: vijay@veraquel.com
Research Institution
 TUFTS UNIVERSITY MEDFORD
 
TUFTS UNIVERSITY 20 Professors Row
MEDFORD, MA 02155-5807
United States

 () -
 Nonprofit College or University
Abstract

DESCRIPTION (provided by applicant): The market for peptide and protein products is 30 billion annually and continues to grow. Automated solid phase peptide synthesis (SPPS) is a mainstay of modern medicinal research, and has been used on micromole up tometric ton industrial scale. Peptide drugs such as Exenatide, a GLP-1 analogue and a life-saver to many type-2 diabetes patients, and Fuzeon for HIV-AIDS would not exist but for SPPS. Error sequences resulting from incomplete synthetic steps limit the efficiency and throughput of SPPS, often requiring laborious and costly separations. Our technology offers a novel solution to the problem via a chemical proofreading that takes place in the background (between standard condensation steps) with no modificationto established methods. Within minutes, any unreacted sites are capped with inert fluorocarbon residues. The error sequences are thus reduced into insoluble constructs that can be removed in a facile manner at the end. Our preliminary studies have co

* Information listed above is at the time of submission. *

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