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Manufacture of Self-Reporting, Drug Loaded Porous Silicon Nanomaterials for Treat

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41EY023482-01
Agency Tracking Number: R41EY023482
Amount: $159,384.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NEI
Solicitation Number: PA12-089
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
665 SAN RODOLFO DR, STE 165
SOLANA BEACH, CA 92075-2047
United States
DUNS: 963348870
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 EMILY ANGLIN
 (619) 890-8844
 emily.anglin@gmail.com
Business Contact
 DALE KOSTMAN
Phone: (619) 890-8844
Email: dkostman@cox.net
Research Institution
 UNIVERSITY OF CALIFORNIA SAN DIEGO
 
UNIVERSITY OF CALIFORNIA SAN DIEGO 9500 GILMAN DR, DEPT 0934
LA JOLLA, CA 92093-0934
United States

 () -
 Nonprofit College or University
Abstract

PROJECT SUMMARY/ABSTRACT Visual impairment is a global epidemic affecting millions of individuals currently. A large portion of these individuals suffer from chronic age-related macular degeneration (AMD), characterized by progressive neovascularization and vascular leakage near the central region (macula) of the retina. Current treatments for AMD, including laser photocoagulation, photodynamic therapy, and surgery, only benefit patients in the advanced stages and temporarily alleviate the progression of the disease. The need for more effective therapies has fostered the development of anti-vascular endothelial growth factor (VEGF) treatments. Although anti- proliferative agents have shown improved efficacy, repeated injections with 6-8 week intervals are often required to maintain therapeutic efficacy of these drugs, leading to inconvenience, higher cost and risk of injection-related complications such as endophthalmitis and retinal detachment. The overall goal of this project is to develop a yearly or bi-y

* Information listed above is at the time of submission. *

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