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A novel therapeutic approach for Acute Lung Injury/ARDS

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41HL124817-01
Agency Tracking Number: R41HL124817
Amount: $201,503.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NHLBI
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
4364 S ALSTON AVE
DURHAM, NC 27713-2220
United States
DUNS: 153401174
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 KENNETH ADLER
 (919) 513-1348
 kenneth_adler@ncsu.edu
Business Contact
 INDU PARIKH
Phone: (919) 768-1335
Email: iparikh@biomarck.com
Research Institution
 NORTH CAROLINA STATE UNIVERSITY RALEIGH
 
NORTH CAROLINA STATE UNIVERSITY RALEIGH SPONSORED PROGRAMS AND REGULATORY COMPLIANCE Administrative Services III 2701 Su
RALEIGH, NC 27695-0001
United States

 () -
 Nonprofit college or university
Abstract

DESCRIPTION (provided by applicant): The objective of the proposed project is to advance the development of novel peptides targeting MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) protein as platform drug molecules for the treatment of Acute Lung Injury (ALI) and its more severe form, Acute Respiratory Distress Syndrome (ARDS), thereby providing the first pharmacologic therapeutic for this condition. ALI/ARDS is a major cause of respiratory failure; worldwide, over 1 million cases occur annually, with ~ 200,000 adult and 15,000 pediatric cases per year in the U.S. This disorder is characterized by a large influx of neutrophils to the lung as part of an acute inflammatory response, injury to epithelial and endothelial cell barriers, and pulmonary edema, all of which lead to respiratory failure. Treatment options are presently limited to mechanical ventilation, a supportive therapy which still results in an in-hospital mortality rate of ~40% in the U.S., with few survivors discharged to home due t

* Information listed above is at the time of submission. *

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