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Discovery of novel small molecule analgesics

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41NS086244-01A1
Agency Tracking Number: R41NS086244
Amount: $244,999.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NINDS
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
10225 Barnes Canyon Road suite A104
SAN DIEGO, CA 92121-2734
United States
DUNS: 963248807
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 SATHEESH RAVULA
 (619) 200-5689
 sravula@epigenbiosciences.com
Business Contact
 SATHEESH RAVULA
Phone: (858) 657-0918
Email: sravula@epigenbiosciences.com
Research Institution
 UNIVERSITY OF CALIFORNIA SAN DIEGO
 
UNIVERSITY OF CALIFORNIA SAN DIEGO 9500 GILMAN DR, DEPT 0934
LA JOLLA, CA 92093-0934
United States

 () -
 Nonprofit College or University
Abstract

DESCRIPTION (provided by applicant): Peripheral nerve injury can lead to anomalous sensations referred to as neuropathic pain. Nerve injury may result from a variety of insults ranging from frank injury to the nerve though sectioning or compression, to chemotherapeutics and autoimmune conditions. Symptoms often include continuous burning pain and abnormal sensory sensations such as allodynia (pain as a result of non-noxious stimuli) and hyperalgesia (an increased response to a normally painful stimulus) Persistent pain after resolution of clinically appreciable signs of chemotherapy poses a therapeutic challenge and immunosuppressive therapies do not meet this medical need. Accordingly, novel treatment options that afford additional benefit in relief of painare needed. In this proposal, the experienced medicinal chemistry capabilities of Epigen Biosciences Inc. will enable the discovery and development of novel small molecules with suitable drug like properties for pain. The chemistry development will b

* Information listed above is at the time of submission. *

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