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Mitochondrial Antioxidant Neurodegenerative Therapeutics: XJB-5-131 Derivatives

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R42NS087700-01
Agency Tracking Number: R42NS087700
Amount: $1,787,822.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NINDS
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
815 SAN LUIS RD
BERKELEY, CA 94707-2031
United States
DUNS: 78883594
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 JANET LEEDS
 (760) 420-4895
 janet.leeds@gmail.com
Business Contact
 JANET LEEDS
Phone: (760) 420-4895
Email: janet.leeds@gmail.com
Research Institution
 UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
 
UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB OCFO Budget Office - Reimbursement Group
BERKELEY, CA 94720-8050
United States

 () -
 Domestic Nonprofit Research Organization
Abstract

DESCRIPTION (provided by applicant): Oxidative damage to mitochondrial is a major source of toxicity in diseases such as Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases (HD). Mitochondria are energy powerhouses of the cell, and decline in their function by oxidative damage is a common feature among neurodegenerative diseases. Despite years of effort, however, generic antioxidants have failed in clinical trials, and there are no effective therapeutics to offset the motor and cognitive declinein afflicted patients. The goal of this STTR application is to fill this medical gap. We have created a paradigm-shifting synthetic platform, in which antioxidants are targeted directly to MT, and reduce oxidative damage to their membranes, proteins, and DNA. The lead compound for this new platform is XJB-5-131, a synthetic, bi-functional molecule harboring a vehicle and a cargo. The cargo is the antioxidant portion, which neutralizes oxidative damage. The vehicle is a peptide mimetic that targets t

* Information listed above is at the time of submission. *

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