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Company
Portfolio Data
Back to Company SearchINTRALASE CORPORATION
Address
INTRALASE CORPORATION 3 MORGAN STIRVINE, CA, 92618
USA
UEI: N/A
Number of Employees: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
SBIR/STTR Involvement
Year of first award: 1992
5
Phase I Awards
3
Phase II Awards
60%
Conversion Rate
$349,502
Phase I Dollars
$1,855,386
Phase II Dollars
$2,204,888
Total Awarded
Awards
FEMTOSECOND LASER ANTERIOR LAMELLAR KERATOPLASTY
Amount: $100,000
DESCRIPTION (provided by applicant): We hypothesize that femtosecond laser technology previously developed for refractive surgical applications can be optimized to perform therapeutic anterior lamellar corneal transplant procedures that are clinically superior to full-thickness and traditional lamellar techniques. Currently, full thickness transplants account for the vast majority of the 45,000 annual corneal transplants performed in the U.S. Most of these procedures could theoretically be replaced with lamellar procedures that include transplantation of either anterior or posterior corneal structures. Replacement of full-thickness corneal transplants with laser lamellar procedures could dramatically reduce complications, lower surgical skill requirements, and speed visual recovery (often delayed with current techniques due to induced astigmatism). In addition, use of a single donor cornea for two patients would significantly improve the shortage that currently exists for donated tissue. To test this hypothesis, we will: Develop hardware and software modifications to the existing femtosecond laser corneal surgery platform : Compare laser-tissue interactions in transparent and translucent tissue to simulate lamellar dissection in normal versus diseased corneas: Model and test self sealing wound architectures for anterior lamellar transplants Model and test self sealing wound architectures for endostromal transplantation through a hinged anterior flap. The goal of the Phase I project will be introduction of software/hardware modifications, as well as the development of surgical techniques for the above procedures that can then undergo clinical testing in a Phase II proposal.
Tagged as:
SBIR
Phase I
2002
HHS
NIH
Compact, Directly Diode-Pumped Sub-Picosecond Amplified Laser Source for Dual Use Applications
Amount: $100,000
The feasibility of novel refractive surgeries has been demonstrated using sub-picosecond laser pulses. However, the introduction of these techniques depends on the development of low cost, reliable, compact laser devices. We propose to design, construct and test a directly diode-pumped Nd:Glass laser system consisting of a prismless oscillator, a single transmission grating stretcher-compressor, and an end-pumped regenerative amplifier. The fully solid-state laser will have an approximately 8 up to 50 mJ at repetition rates of 3 kHz. Corneal surgical procedures with the laser will be evaluated and the results used to guide laser design specifications for a commercial prototype, to be developed during Phase II. If the proposed device satisfies clinical and commercial requirements, surgical correction of a wide variety of refractive errors may become more effective, safe and affordable. By eliminating the need for eyeglasses and other corrective devices, the pool of potential military personnel can be increased, while the capabilities of current personnel can be strengthened. Since the new laser device is designed to run on a simple car battery, dual use applications, such as high precision military ranging and remote sensing of air pollutants are also possible.
Tagged as:
SBIR
Phase I
1998
DOD
USAF
ER:YAG LASER LENS EMULSIFICATION
Amount: $750,000
THE OBJECTIVE OF THIS RESEARCH IS TO DEVELOP AN INNOVATIVE TECHNIQUE AND ASSOCIATED INSTRUMENTATION FOR ANTERIOR CAPSULOTOMY AND LENS EMULSIFICATION WHICH ALLOWS THE MAJORITY OF OPTHALMOLOGISTS TO PERFORM THESE PROCEDURES WITH GREATER SAFETY AND EFFICACY. THE PHASE I STUDY FOCUSES ON ER:YAG LASER LENS EMULSIFICATION. THE FOUR OBJECTIVES OF THIS STUDY ARE: TO IDENTIFY THE ER:AG PULSE INDUCED ACOUSTIC EFFECT IN LENS EMULSIFICATION, TO ESTABLISH THE OPTIMAL LASER DOSIMETRY, TO EVALUATE THROUGH HISTOLOGICAL TECNIQUES THE PRESENCE OR LACK THEREOF OF ADVERSE EFFECTS TO ADJACENT STRUCTURES IN THE EYE, AND TO DESIGN A CLINICALLY EFFICACIOUS FLEXIBLE DELIVERY SYSTEM FOR LENS EMULSIFICATION. THIS BASIC RESEARCH IS THE FOUNDATION FOR FURTHER IN VIVO TESTING OF THE TECHNIQUE AND INSTRUMENTATION DURING THE PHASE II STUDY. THE RESULTS FROM THE IN VITRO AND IN VIVO STUDIES WILL ALLOW TIMELY DEVELOPMENT AND OPTIMIZATION OF THE OPTHALMIC INSTRUMENTATION. PREMIER LASER SYSTEMS HAS ALREADY CLINICALLY DEMONSTRATED THE ADVANTAGES OF THE ER:YAG LASER AND FLEXIBLE FIBEROPTIC DELIVERY IN PERFORMING A SMOOTH CIRCULAR ANTERIOR CAPSULOTOMY ON 10 PATIENTS. THE SUBSEQUENT PROCEDURE FOR INTRAOCULAR LENS REPLACEMENT INVOLVES THE EMULSIFICATION AND ASPIRATION OF THE OPAQUE LENS. IN PURSUING LASER LENS EMULSIFICATION, OUR PRELIMINARY DATA ARE VARIABLE BUT ILLUSTRATE THAT THE ER:YAG LASER HAS THE POTENTIAL TO BOTH ABLATE AND ACOUSTICALLY EMULSIFY ALL GRADES OF LENSES INCLUDING DENSE GRADE THREE AND FOUR LENSES, WHICH ARE NOT AMENABLE TO PHACOEMULSIFICATION.
Tagged as:
SBIR
Phase II
1995
HHS