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Epicypher, Inc.

Company Information
Address
6 Davis Dr
Durham, NC 27709-0003
United States


https://www.epicypher.com

Information

UEI: UWNWSADJYYZ3

# of Employees: 31


Ownership Information

HUBZone Owned: No

Socially and Economically Disadvantaged: No

Woman Owned: No



Award Charts




Award Listing

  1. Novel recombinant sensors to study histone ubiquitin signaling

    Amount: $1,276,822.00

    PROJECT SUMMARYMonoubiquitination (Ub) of histones is an important post-translational modification (PTM) that regulates multiple DNA-related processes including DNA replication, transcription, and rep ...

    SBIRPhase II2023Department of Health and Human Services National Institutes of Health
  2. Development of ultra-efficient antibodies for single cell mapping applications

    Amount: $1,007,748.00

    PROJECT SUMMARYHistone post-translational modifications (PTMs) are some of the most widely studied epigenomic factors, and alterations in histone PTM abundance / distribution have been implicated in n ...

    SBIRPhase II2023Department of Health and Human Services National Institutes of Health
  3. Multiomic genomic mapping with long read sequencing

    Amount: $1,272,936.00

    PROJECT SUMMARYGenomic mapping of histone post-translational modifications (PTMs), chromatin-associated proteins (CAPs), and DNA methylation (DNAme) is a powerful approach for biomedical research and ...

    SBIRPhase II2023Department of Health and Human Services National Institutes of Health
  4. Scalable and quantitative chromatin profiling from formalin-fixed paraffin-embedded samples

    Amount: $406,324.00

    PROJECT SUMMARYThe development of tools to map the location of histone post-translational modifications (PTMs) genome- wide has ushered in a new era of epigenetic research, placing histone PTMs and as ...

    SBIRPhase I2023Department of Health and Human Services National Institutes of Health
  5. Epigenomic analysis of cell-free nucleosomes for cancer research

    Amount: $406,374.00

    PROJECT SUMMARYCell-free DNA (cfDNA) levels are elevated in the blood of individuals with cancer, leading to increased interest in liquid biopsy (LB)-based assays for disease diagnostics and monitorin ...

    SBIRPhase I2023Department of Health and Human Services National Institutes of Health
  6. Rapid and robust assay for measurement of in vivo activity of chromatin-interacting proteins

    Amount: $1,008,869.00

    PROJECT SUMMARYThe activity of chromatin-associating proteins (CAPs) is fundamental to regulation of gene expression. Elucidating CAP activity is central to understanding the regulatory mechanisms tha ...

    SBIRPhase II2023Department of Health and Human Services National Institutes of Health
  7. Ultrasensitive multiomic platform using epitope-targeted DNA methylation mapping

    Amount: $1,131,793.00

    Candidate Eligibility StatementThe goal of this diversity supplement application is to provide career development support for Dr. Allison Hickman, a bioinformatician who aspires to (and with support c ...

    SBIRPhase II2023Department of Health and Human Services National Institutes of Health
  8. High-resolution genomic mapping of ssDNA and associated proteins for Alzheimer's disease research

    Amount: $500,000.00

    PROJECT SUMMARYEpiCypher is collaborating with Dr. Jessica Tyler (an expert in aging, DNA repair and epigenetics), to develop CUTandRUssNTM (Cleavage Under Targets and Release Using single-stranded Nu ...

    SBIRPhase I2022Department of Health and Human Services National Institutes of Health
  9. Engineered super-affinity reagents for detection of histone post-translational modifications

    Amount: $2,048,658.00

    PROJECT SUMMARYHistone post-translational modifications (PTMs) are widely studied due to their diverse roles in controlling gene expression. The study of PTMs largely relies on antibodies; however, we ...

    SBIRPhase II2022Department of Health and Human Services National Institutes of Health
  10. Quantification of combinatorial epigenetic modifications using defined nucleosome standards

    Amount: $2,048,980.00

    PROJECT SUMMARYPost-translational modification of histone tails (histone PTMs) and DNA methylation (DNAme) on nucleosomes form a sophisticated molecular code that regulates gene transcription. Aberran ...

    SBIRPhase II2022Department of Health and Human Services National Institutes of Health
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