You are here
Epicypher, Inc.
UEI: UWNWSADJYYZ3
# of Employees: 31
HUBZone Owned: No
Socially and Economically Disadvantaged: No
Woman Owned: No
Award Charts
Award Listing
-
High-resolution genomic mapping of ssDNA and associated proteins for Alzheimer's disease research
Amount: $500,000.00PROJECT SUMMARYEpiCypher is collaborating with Dr. Jessica Tyler (an expert in aging, DNA repair and epigenetics), to develop CUTandRUssNTM (Cleavage Under Targets and Release Using single-stranded Nu ...
SBIRPhase I2022Department of Health and Human Services National Institutes of Health -
Engineered super-affinity reagents for detection of histone post-translational modifications
Amount: $1,024,329.00PROJECT SUMMARYHistone post-translational modifications (PTMs) are widely studied due to their diverse roles in controlling gene expression. The study of PTMs largely relies on antibodies; however, we ...
SBIRPhase II2022Department of Health and Human Services National Institutes of Health -
Quantification of combinatorial epigenetic modifications using defined nucleosome standards
Amount: $1,024,490.00PROJECT SUMMARYPost-translational modification of histone tails (histone PTMs) and DNA methylation (DNAme) on nucleosomes form a sophisticated molecular code that regulates gene transcription. Aberran ...
SBIRPhase II2022Department of Health and Human Services National Institutes of Health -
A molecular toolbox to accelerate drug development for histone lysine methylation regulators
Amount: $1,025,085.00PROJECT SUMMARYNucleosomes (Nucs) are the repeating unit of chromatin structure and are decorated with diverse post- translational modifications (PTMs) to regulate gene expression. The enzymes that ad ...
SBIRPhase II2022Department of Health and Human Services National Institutes of Health -
Quantitative mapping of dynamic epigenetic states in rare and stimulated immune cells
Amount: $1,022,665.00PROJECT SUMMARYHistone post-translational modifications (PTMs) play important roles in modulating chromatin structure and gene expression, and dysregulation of these marks is associated with immune an ...
SBIRPhase II2022Department of Health and Human Services National Institutes of Health -
Development of a high-throughput epigenomic mapping platform to molecularly phenotype Crohn's disease
Amount: $978,127.00SUMMARYThe inflammatory bowel diseases (IBDs), Crohn’s disease (CD) and ulcerative colitis (UC), are chronic conditions of the gastrointestinal (GI) tract. CD can occur anywhere along the GI tract a ...
SBIRPhase II2022Department of Health and Human Services National Institutes of Health -
Multiomic genomic mapping with long read sequencing
Amount: $406,352.00PROJECT SUMMARYGenomic mapping of histone post-translational modifications (PTMs), chromatin-associated proteins (CAPs), and DNA methylation (DNAme) is a powerful approach for biomedical research and ...
SBIRPhase I2022Department of Health and Human Services National Institutes of Health -
A novel platform for quantification of acute neuronal transcriptional responses
Amount: $326,506.00PROJECT SUMMARYAcute transcriptional responses underlie essential neurobiological processes from development to learning and memory, and have been hypothesized to be a driving force behind substance u ...
SBIRPhase I2022Department of Health and Human Services National Institutes of Health -
Ultrasensitive multiomic platform using epitope-targeted DNA methylation mapping
Amount: $529,787.00Candidate Eligibility StatementThe goal of this diversity supplement application is to provide career development support for Dr. Allison Hickman, a bioinformatician who aspires to (and with support c ...
SBIRPhase I2022Department of Health and Human Services National Institutes of Health -
Development of ultra-efficient antibodies for single cell mapping applications
Amount: $306,500.00PROJECT SUMMARYSingle cell (SC) epigenomics is a rapidly emerging field, driven by recent technology advances and the diverse roles that epigenetic features play in controlling gene activation. Histon ...
SBIRPhase I2021Department of Health and Human Services National Institutes of Health
