Awards Information

SUMMARY About of Americans age have Mild Cognitive Impairment MCI of which progress to dementia annually A growing number of companies are developing new therapeutics aiming to intervene early in the development of Alzheimerandapos s disease the most common form of dementia and there is a great need for accurate minimally invasive diagnostics for primary screening of individ ...

DESCRIPTION provided by applicant The objective of this SBIR fast track project is to expediently advance pre clinical development of a new therapeutic for diabetic neuropathy Of the million Americans who suffer from diabetes approximately will be diagnosed with neuropathy which is characterized by nerve degeneration Despite the high prevalence of the disease there is currently no F ...

PROJECT SUMMARY Clinical Evaluation of a Resorbable Inferior Vena Cava Filter Pulmonary embolism PE is the rd leading cause of death claiming the lives of at least Americans annually more than breast cancer AIDS and vehicle fatalities combined Metallic Inferior Vena Cava IVC filters have been proven effective in reducing PE to about in at risk populations however they ...

DESCRIPTION provided by applicant Many patients requiring stem cell transplantation for hematological malignancies are unable to find a suitable HLA matched sibling or unrelated donor Transplants using stem cells from umbilical cord blood provide an alternative for these patients allowing transplantation to proceed with less stringent HLA matching requirements Unfortunately in addition to t ...

DESCRIPTION (provided by applicant): The treatment of large cartilage lesions is a difficult clinical problem for which there are few good solutions. Left untreated, these lesions tend to degenerate to chronic pain and osteoarthritis (OA), ultimately requiring a total joint replacement. For patients suffering from knee OA, and, in particular, unicompartmental OA, unicondylar knee arthroplasty (UKA ...

DESCRIPTION Our goal in this project is to develop a web application to guide researchers in the efficient and effective design of animal studies that balance the competing needs of minimizing animal use and providing rigorous repeatable results Three basic ideas which translate directly into our three specific aims form the foundation of our proposed tool First an foremost is to place scie ...

DESCRIPTION provided by applicant Microarray technology has dramatically advanced the study of protein interactions leading to discovery and validation of new biomarkers and therapeutic drugs Typically protein microarrays are pre spotted with target molecules in one device and then tested with probe molecules using another device During each testing cycle the entire microarray becomes expos ...

The primary goal of this fast track project is to commercialize a cloud based software suite complemented with on call expert services to guide life science researchers that may have minimal statistical and experimental design ED knowledge to rigorously plan optimize justify manage and report results for complex animal studies Inadequately planned experiments e g lack of randomization b ...

The broader impact/commercial potential of this project is the expansion of autonomous unmanned aerial systems (UAS, or drones) to new maritime operational environments and commercial markets. The proposed technology will enable small UAS to operate from vessels moving at sea, without the need for a dedicated pilot or installed hardware, even while far from shore and beyond the reach of establishe ...

This project intends to design and develop a programmable electronics and robotics kit that catalyzes the learning of computational thinking, engineering design, and making at a price point that will be affordable for large numbers of elementary school classrooms throughout the nation. Such an educational robotics kit benefits society by positively influencing science, technology, engineering, and ...