List

No other group of diseases encompasses a greater pathophysiology than do the rheumatic diseases Spanning multiple organ systems clinical decisions often rely on coordinated efforts from primary care providers and rheumatologists to rule in or rule out differential diagnoses when treating inflammatory conditions such as rheumatoid arthritis RA and systemic lupus erythematosus SLE RA is a sym ...

Photodynamic Therapy PDT is a promising modality for cancer treatment Oxygen molecules in the metastable singlet delta state O are believed to be the species that destroys cancerous cells during PDT Despite the benefit of targeted PDT that kills tumors selectively with minimum effect on surrounding healthy tissues at the present time it is difficult if not impossible to predict the res ...

Recent advances in DNA sequencing technology have not been matched by improved analytic techniques to quickly and accurately interpret patient genome data to inform diagnosis prognosis and therapy making decisions in the clinic and to identify candidate biomarkers of disease in research laboratories Development of automated techniques to facilitate interpretation of this data will benefit patien ...

Abstract The study of protein ligand binding is one of the central problems in computational biology because of its importance in understanding intermolecular interactions and because of its practical payoff in drug discovery efforts The transformative impact accurate target ligand structure can have in the design of next generation medicines cannot be overstated If we could routinely and accur ...

Project Summary This Fast Track SBIR project long term objective is to develop and test of a minimum viable product MVP of The Oaks a perioperative digital education assessment and guided exercise software application for adults with osteoarthritis of the knee KOA awaiting total knee replacement TKR surgery This product is relevant to the mission of the NIA because it addresses the call ...

Project Summary We propose in this SBIR effort to develop a smartphone or tablet based app for caregivers to perform non invasive and quantitative measurements of patientsandapos chronic wounds especially on diabtetic foot ulcers either at care facilities or at patientsandapos home Since chronic wounds take months or even longer to heal it is highly likely that more and more patients will be ...

Respiratory syncytial virus RSV can cause lower respiratory illness LRI in otherwise healthy children and developing an effective prophylactic vaccine to mitigate RSV disease in infants is a public and global health priority according to the World Health Organization The overall goal of this project is to develop a safe and efficacious RSV vaccine for immunizing sero negative months to ye ...

Project Summary The broad long term objective of this Fast Track proposal is to develop an innovative self management intervention SMI technology Inspiration Point for the treatment and study of Chronic Obstructive Pulmonary Disease COPD This application directly addresses the NHLBI SBIR requests for proposals for the development of innovative technologies for COPD the development of techn ...

Despite the myriad major advances in cardiology the prognosis for patients with severe medically refractive heart failure HF is exceedingly poor Approximately deaths occur annually in patients with HF who have endured an impaired quality of life often accompanied by significant economic and personal losses due to recurrent hospitalizations At least of these deaths were directl ...

Project Summary Alzheimer s disease AD is expected to rise in prevalence from to million Americans by leading to of deaths among adults over This epidemic is projected to overwhelm healthcare and economic resources with costs reaching $ billion in the US in and $ trillion by There is no cure for AD and no new drugs have been successful in treating the advance ...