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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 1 - 10 of 3178 results
  1. Novel flavonoids as anti-inflammatory agents in alcoholism

    SBC: NAPROGENIX, INC.            Topic: NIAAA

    DESCRIPTION (provided by applicant): Flavonoids are ubiquitous secondary metabolites in plants with many known health benefits, which are mostly ascribed to their potent anti-oxidant activity. However, a search for novel nicotinic ligands, using high throughput pharmacological screening of a native plant extract library, and subsequently a pure flavonoid library, led to the highly surprising con ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Web-Based Training in Alcohol SBIRT for Youth Aged 9-18

    SBC: Oregon Center For Applied Science, Inc            Topic: NIAAA

    DESCRIPTION (provided by applicant): Underage alcohol consumption is a public health concern with numerous negative sequelae, including adoption of other risky behaviors (smoking, other drug use, at-risk sexual behavior, drinking and driving), increased rates of depression or suicidal ideation, poor academic achievement, and behavioral problems (delinquency, violence, crime). Adolescents who drink ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Screening for Alcohol-Related Liver Disease Using Breath Signatures by DMS

    SBC: APPLIED NANOTECH, INC.            Topic: NIAAA

    DESCRIPTION (provided by applicant): Alcohol abuse is rampant in the U.S., estimates run as high as 1 in 20 adults, and cost tens of billions of dollars in treatment and economic loss. One especially intransigent problem has been alcohol-induced organ disease such as alcoholic hepatitis and cirrhosis. These diseases can currently be diagnosed, but this requires invasive procedures such as liver bi ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. A Novel Small Molecule Therapeutic for Alcoholic Chronic Pancreatitis

    SBC: Angion Biomedica Corp.            Topic: NIAAA

    DESCRIPTION (provided by applicant): Chronic Pancreatitis (CP) is characterized by continuous or recurrent inflammation of the pancreas that leads to permanent destruction of the pancreas resulting in exocrine and endocrine insufficiency. CP is a common disorder associated with significant morbidity and mortality with an incidence of 8.2 and a prevalence of 27.4 per 100 000 population. The etiolog ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Development of Gap Junction Inhibition Therapy for Alcoholic Liver Disease

    SBC: HEPROTECH, INC.            Topic: NIAAA

    ? DESCRIPTION (provided by applicant): Alcoholic liver disease is a highly prevalent and costly condition affecting millions of people globally. Alcohol results in high morbidity and mortality an is responsible for nearly 4% of all deaths worldwide. Despite the tremendous societal and economic burden, there is no approved therapeutics for alcoholic liver disease. Instead, the standard of care ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Gamma-ketoaldehyde scavengers for alcoholic liver disease

    SBC: MTI Biotech Incorporated            Topic: NIAAA

    DESCRIPTION (provided by applicant): Chronic alcohol overconsumption is the third largest risk factor for disease burden worldwide and is a frequent comorbidity of liver disease and cancer. While abstinence is a cornerstone of treatment, there is considerable interest in identifying other therapeutic interventions for alcoholic liver disease (ALD). Such advances are complicated by an incomplete un ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Clinically suitable approach for gene-mediated therapy of cirrhosis.

    SBC: ADVANTAGENE, INC            Topic: NIAAA

    Abstract Persistent injury to the liver can cause chronic inflammation and dysregulated deposition of extracellular matrix (ECM), leading to accumulation of fibrotic scar tissue and eventually cirrhosis. While fibrosis is a normal wound healing response, in excess, it can further injure tissue and activate pro-fibrotic cells, resulting in a positive feedback loop. Scar tissue is not static, ECM re ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Mobile Intervention to Enhance Physical Activity in the Chronically Ill

    SBC: Oregon Center For Applied Science, Inc            Topic: NIA

    PROJECT SUMMARY This project aims to fill the urgent need for a safe and engaging intervention that promotes physical activity in a population of patients with chronic diseases (e.g., diabetes, asthma, osteoarthritis, and chronic heart failure). Compelling evidence suggests that physical activity is an effective therapeutic intervention for numerous chronic diseases. However, in spite of the wide ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Novel Algorithm for Free Testosterone Determination

    SBC: FUNCTION PROMOTING THERAPIES LLC            Topic: NIA

    DESCRIPTION (provided by applicant): The measurement of testosterone levels is central to the diagnosis of androgen disorders in men and women. Circulating testosterone is bound largely to sex hormone binding globulin (SHBG) and albumin; only the unbound or free fraction is biologically active. Therefore, in conditions that affect SHBG concentrations, such as aging, obesity, and diabetes, the dete ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. A synthetic biology platform to identify novel anti-aging natural products

    SBC: Radiant Genomics, Inc.            Topic: NIA

    DESCRIPTION (provided by applicant): The ultimate goal of research into the biology of aging is to identify pharmaceutical interventions to increase both lifespan and healthspan of humans. The natural product rapamycin has been shown to significantly extend the lifespans of all model organisms tested including fungi, flies, worms, and mice. However, chronic treatment with rapamycin also causes unw ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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