Award Data

DESCRIPTION (provided by applicant): A technique is proposed for the development of an intraoperative, 3-dimensional registration of C-arm fluoroscopic images with spatially-registered ultrasound visualization and implant guidance of radioactive implants and on-line implant assessment during the procedure for treatment of prostate cancer. With present techniques using transrectal ultrasound guidan ...

DESCRIPTION (provided by applicant): The major goal of our proposed project is to advance the development of novel compounds for the treatment of amyloidosis and other protein aggregation diseases. Preliminary work demonstrated that two chalcones inhibited amyloid fibril formation, in vitro, and that further work is warranted. The amyloid diseases that arise from nonimmunoglobulin proteins includ ...

DESCRIPTION (provided by applicant): Zirconia bio-ceramics (e.g. Prozyr) have the highest toughness and strength compared to other bio-ceramics such as alumina (e.g. Biolox) or zirconia-toughened alumina (Biolox-Delta). However, as highlighted by the recent recall of St. Gobain zirconia heads, a critical need remains to develop bio-ceramics with both significantly reduced wear characteristics and ...

DESCRIPTION (provided by applicant): Use of botanical products such as exogenous antioxidants has gained considerable momentum in the last few years in therapy of human degenerative diseases. Among these antioxidants, tumeric, neem, guggul, alpha-tocopherol, Beta-carotene, and ascorbic acid have been shown to have a special relevance in maintaining the redox e ...

DESCRIPTION (provided by applicant): Vitamin D deficiency is now recognized as a significant health problem for middle-aged and older adults. Vitamin D deficiency exacerbates osteoporosis and causes the bone disease, osteomalacia. Vitamin D deficiency increases risk of skeletal fractures. It is well known that the ultraviolet B portion of the solar spectrum is responsible for the cutaneous product ...

A unique approach to the problem of portable signal identification training (PSIT) is proposed through the use of an integrated signals database, training software, and the re-use of operator interface software. Two training scenarios are addressed:standalone training mode and transmit training mode. The proposed approach is based entirely on COTS hardware. The approach also minimizes the hardw ...

Under Phase I effort, Applied Thin Films, Inc. (ATFI) discovered a new process to deposit oxide buffer layers for HTS coated conductors that is economical, scalable, and has demonstrated excellent performance with YBCO films (current densities of 1MA/cm2). The process is called ECONO (Epitaxial Conversion to Oxide via Nitride Oxidation) which is now being considered as the primary contender for t ...

Under Phase I effort, Applied Thin Films, Inc. (ATFI) discovered a new process to deposit oxide buffer layers for HTS coated conductors that is economical, scalable, and has demonstrated excellent performance with YBCO films (current densities of 1MA/cm2). The process is called ECONO (Epitaxial Conversion to Oxide via Nitride Oxidation) which is now being considered as the primary contender for t ...

The proposed effort relates to the use of Cerablak?, an amorphous-based black oxide material, as a coating for protection of metallic thermal protection systems (TPS) to be used in reusable launch vehicles (RLVs). This material shows potential to be a coating that meets all of NASA?s requirements for TPS protection in a single material system. The basic technical requirements for a coating to prot ...

In this Phase I SBIR project, a low-cost oxide-oxide interface coating-free ceramic matrix composite (CMC) will be developed for radomes for next-generation high speed missiles. The innovative and key component of the CMC is a newly patented matrixmaterial (CerablakT) based on aluminum phosphate compositions. The key properties of CerablakT relevant to radome applications is its low dielectric c ...