Award Data

Warfighters in far-forward deployed settings are at risk for exposure to weaponized opioids and subsequent opioid intoxication. Naloxone is ordinarily effective as an immediate opioid poisoning antidote. However, synthetically derived opioids such as carfentanil and fentanyl-derivatives have a half-life that exceeds that of naloxone, subjecting victims to a phenomenon known as renarcotization, req ...

Concealed chemical threats represent a significant hazard to field operators. Even brief exposure to chemicals can cause lasting physical, physiological, and mental damage. Field operators require tools and techniques to more quickly, safely, and reliably locate and identify chemical threats. Chemical detectors typically excel at either threat classification or threat localization, but seldom both ...

Warfighters in far-forward deployed settings are at risk for exposure to weaponized opioids and subsequent opioid intoxication. Naloxone is ordinarily effective for immediate opioid reversal. However, synthetically derived opioids such as carfentanil and fentanyl-derivatives have a half-life that exceeds naloxone’s, subjecting victims to a phenomenon known as renarcotization, requiring repeated ...

Department of Defense personnel must wear respiratory protection continuously when deployed in regions with the danger of chemical or biological attack. Manufacturing respirators/masks using conventional molding methods limits the features that can be designed into the protection. Additive manufacturing provides an ideal approach for manufacturing respirators. Additive Manufacturing enables the ab ...

In a pandemic or exposure to weaponized Marburg virus the morbidity, mortality and social unrest that will ensue before vaccines orMilitary operating on foreign soil as well as to the population of the US Homeland. Practically all threat agents of biological origin (except forcertain non-proteinaceous toxins, typically produced by marine organisms and fungi) have their structure and vital function ...

Future engagements (especially with near-peer threats) present the possibility of a wide range of anticipated operational situations involving the presence of chemical threat agents. With this, deployment of Military Working Dogs (MWDs) is likely. This creates a situational awareness that MWDs are potentially at risk from exposure to a wide range of hazardous chemicals. Potential threat agents inc ...

Alphaviruses, infection with which may cause encephalitis and death, are recognized as potential biological warfare agents. There are noapproved medical countermeasures against Alphaviruses. In Phase I, using Abzymes proprietary in vivo Self-Diversifying Camelid SingleDomain Antibody Library (SDALib) platform, broadly reactive single domain camelid VHH antibodies against equine encephalitis viral ...

Existing U.S. military chemical point sensors such as the JCAD can only provide qualitative detection/ identification results for CWAs and TICs. MESH is proposing to develop a low cost, active FTIR system with a variable optical path within a short open external distance from the sensor. This system will be capable of multicomponent analysis including chemical identification and quantification. Lo ...

Mycotoxins are fungal toxins to which exposure frequently results in incapacitation or even in death. Natural outbreaks of mycotoxin poisoningare common worldwide. Due to its physical-chemical properties, high toxicity and relative ease to produce, mycotoxin T-2 is classified as apotential biological warfare agent. Currently there are no FDA approved medical countermeasures available for T-2 mycot ...

Alphavirus infection, which may cause encephalitis and death, are recognized as potential biological warfare agents. There are no approved medical countermeasures against diseases caused by Alphaviruses. In this project, thermostable single domain antibodies capable of crossing the blood brain barrier (BBB) and neutralizing encephalitic viruses will be developed using Abzymes proprietary in vivo S ...