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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Development of a protein drug for pancreatic cancer treatment

    SBC: ProDa BioTech L.L.C.            Topic: NCI

    Abstract Pancreatic cancers are devastating diseases with five year survival rate less than Currently there is no effective treatment for advanced disease One major barrier to efficacy of anti tumor therapeutics is the dense desmoplastic stromal response Evidence suggests that cancer associated pancreatic stellate cells CAPaSC produce the stromal collagen The ECM laid down by CAPaSC is c ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Monoclonal lamprey VLR antibodies specific for mucin type O linked glycan core structures

    SBC: Novab, Inc.            Topic: 300

    PROJECT SUMMARY We will develop and commercialize to the research community a new class of glycan specific binding reagents that incorporate the recognition function of variable lymphocyte receptors VLRs the antigen receptors of the adaptive immune system of jawless vertebrates lamprey and hagfish Such reagents are essential to detecting localizing quantifying and establishing biological ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Preventing Vascular Complications in Type Diabetes Muscle Metabolic Monitoring

    SBC: Infrared Rx, Inc.            Topic: NIDDK

    Project Summary Abstract While much has been accomplished in managing hyperglycemia morbidity and mortality in patients with type diabetes T D often results from cardiovascular complications Evidence suggests peripheral artery disease and skeletal muscle mitochondrial dysfunction One reason is the lack of reliable tools to characterize skeletal muscle microcirculation and mitochondrial capa ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Blood biopsy test for pan cancer mutations with error checking probes

    SBC: GENETAG TECHNOLOGY, INC.            Topic: 102

    Blood biopsy test for pan cancer mutations with error checking probes Confidential PI Shafer David A PhD PROJECT SUMMARY GeneTAG Technology www genetagtech com has developed a series of molecular diagnostic assays for cancer and infectious diseases based on DNA amplification and proprietary detection methods Our primary system internal DDS iDDS probes comprises two interacting component ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Matrix free Laser Desorption and Ionization Substrates for Mass Spectroscopy

    SBC: InRedox LLC            Topic: 400

    Project Summary This multi phase SBIR project targets an important problem in life science increasing resolution and throughput of mass spectroscopy MS using inexpensive nanostructures substrates for matrix free laser desorption and ionization LDI Soft ionization techniques for MS such matrix assisted LDI MALDI have become among the most important tools in applications from proteomics ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Point of Care Prognostic Tool for Sepsis

    SBC: Mbio Diagnostics, Inc.            Topic: 200

    Sepsis is a devastating cause of morbidity and mortality in intensive care units ICUs with estimates of U S incidence ranging from to million cases annually The heterogeneity of clinical presentation etiology patient history severity etc creates a major challenge for patient management and has significantly complicated development of new therapies almost all of which have f ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Addressing Gaps in Pediatric Prescribing Using Scalable and Interoperable Prescription Decision Support

    SBC: RXREVU, INC.            Topic: NICHD

    ABSTRACT Significance Electronic prescribing is now widely adopted by US healthcare systems but clinical functionality of e prescribing falls short in the realm of pediatrics Medication prescribing is intrinsically more complex for pediatric patients due to weight based dosing the lack of widely adopted medication formulation recipes inconsistent off label ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Prodrug treatment for CML

    SBC: INHIBIKASE THERAPEUTICS            Topic: 102

    Inhibikase Therapeutics is a clinical stage bio pharmaceutical company that has developed a novel prodrug formulation for the popular anticancer agent Gleevec Gleevec treatment is commonly accompanied by significant burdensome gastrointestinal side effects that erode therapy success due to poor patient compliance Inhibikaseandapos s prodrug of Gleevec completely blunts these gastrointestina ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Non invasive risk assessment tool for pediatric heart failure

    SBC: CORAMIR BIOMEDICAL, INC.            Topic: NHLBI

    ABSTRACT Heart Failure HF in pediatric patients is a devastating disease that is difficult to evaluate even with invasive hospital procedures Importantly and unique to the pediatric population approximately of pediatric HF patients spontaneously recover normal heart function within year of diagnosis Unfortunately there is no reliable clinical parameter or biomarker that allows pedia ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Development of the first thermolytic to suppress shivering and seizure

    SBC: Be Cool Pharmaceutics LLC            Topic: NHLBI

    Summary The temperature management market is expected to reach $ billion by yet no pharmaceutical has yet been developed specifically for this market A adenosine A AR agonists are well known to attenuate seizure and protect the brain from injury but development of these drugs has been limited by side effects including hypothermia bradycardia and hypotension Inspired by our discover ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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