Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. "Modulation of Immune Checkpoints by Self Deliverable RNAi for Adoptive Cell Transfer"

    SBC: ADVANCED RNA TECHNOLOGIES LLC            Topic: 102

    Two of the most promising approaches to cancer immunotherapy are immune checkpoint blockade by monoclonal antibodies and the adoptive transfer of immune cells The recent successes in treating melanoma with anti PD and anti CTLA antibodies as well as the extremely successful application of T cells engineered to express the CAR receptor targeting CD to treat B cell lymphomas initiated a waterfal ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A BIODEGRADABLE WOUND TREATMENT

    SBC: ATRIX LABORATORIES, INC.            Topic: N/A

    WE WILL DEVELOP A BIODEGRADABLE WOUND TREATMENT THAT CAN BE AEROSOLIZED DIRECTLY ONTO A WOUND SURFACE. IT WILL FORM A TOUGH, FLEXIBLE FILM THAT WILL SEAL THE WOUND AND PROVIDE FOR PROPER WATER LEVELS AT THE WOUND SURFACE. AN ANTIBIOTIC WILL BE INCORPORATED INTO THE BIODEGRADABLE POLYMER AND WILL BE SLOWLY RELEASED INTO THE WOUND BOTH TO ELIMINATE EXISTING INFECTION AND TO PREVENT LATER INFECTION. ...

    SBIR Phase I 1991 Department of Health and Human Services
  3. A Comprehensive 5K plus Glycan Microarray

    SBC: Z Biotech, LLC            Topic: 300

    Project SummaryAbstract There is growing need of high throughput analytical platforms to study interactions of cell surface glycans and glycan binding proteinsWe propose here to develop aKglycan array to facilitate functional glycomics researchTwo hurdles for development of a comprehensive glycan array arelack of a sensitive glycan array substrate enabling multivalent binding eventsandlack of a co ...

    SBIR Phase I 2017 Department of Health and Human Services
  4. A Disposable Amperometric Lithium Ion-selective Electrode for Home Testing

    SBC: ADA Technologies, Inc.            Topic: N/A

    Not Available

    SBIR Phase I 2009 Department of Health and Human Services
  5. A Low-Cost Upper-Extremity Prosthetic Interface

    SBC: ADA Technologies, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Remarkable advances in signal processing techniques, materials sciences, battery technologies, and computer-aided design and computer-aided manufacturing (CAD/CAM) processes have led to significant developments in assistive technologies. Coordinated research and commercialization have dramatically increased prosthetic function, utility, personalization, comfor ...

    SBIR Phase I 2009 Department of Health and Human Services
  6. A Microneedle Array System for Transcutaneous Nerve Mapping

    SBC: Axion Biosystems, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The proposed study utilizes novel electronics and microfabrication techniques to create a non-invasive, automated platform for targeted monitoring and manipulation of human neural tissue. This research will enable rapid advancements in both basic research and clinical medical devices, with applications to neuropathological diagnostics, advanced therapeutics, an ...

    SBIR Phase I 2009 Department of Health and Human Services
  7. A New Web 2.0 Platform for Analyzing Genomics Data with Application to the Study

    SBC: MYATT AND JOHNSON, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): A major research focus for gaining insight into the molecular basis for cancer, with the goal of identifying new treatments, is the systematic profiling of cancer cells. This includes the generation of compound potency data and gene/protein expression data. This has led to the generation of massive amounts of disparate data that must be associated in context se ...

    STTR Phase I 2009 Department of Health and Human Services
  8. A Next-Generation Split Hook Prehensor with Enhanced Grasp Functionality

    SBC: ADA Technologies, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Owing to certain intrinsic advantages, a surprisingly large number of upper-extremity amputees prefer simple cable operated prostheses and split hook terminal devices for many activities. For disadvantaged amputees in the United States and in developing countries, such systems often present the only viable restorative option. ADA Technologies and its supportin ...

    SBIR Phase II 2009 Department of Health and Human Services
  9. A rapid method for monitoring in vitro glycoengineering

    SBC: GLYCOSENSORS AND DIAGNOSTICS, LLC            Topic: 300

    PROJECT SUMMARY The glycosylation of therapeutic proteinssuch as antibodiesis well known to affect bioactivityhoweveruniform glycosylation is challenging to achieve when glycoproteins are produced in bioreactorsOne approach to obtaining well defined homogeneous glycosylation is to use glycosidases and glycosyl transferasesglycoenzymesto modify the glycosylation of the proteinpost productionThis ap ...

    SBIR Phase I 2017 Department of Health and Human Services
  10. A self-contained wireless modular separation based sensor system

    SBC: Pinnacle Technology, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Recent advances have shown effective neurotransmitter analysis using capillary electrophoresis (CE). In a CE system, analyte is drawn through a narrow channel using ion movement resulting in an electroosmotic flow (EOF) generated by a high voltage electric field. Most microchip CE methods reported in the literature use the same separation and detection method f ...

    SBIR Phase I 2009 Department of Health and Human Services
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