Award Data

THIS PROJECT IS INTENDED TO DEVELOP A PROTEASE INHIBITOR THAT CAN BE SAFELY ADMINISTERED TO PATIENTS WHO HAVE ONGOING ELASTIN DESTRUCTION AS A MAJOR FEATURE OF THEIR DISEASE. SUCH DISEASES INCLUDE THOSE IN WHICH PHAGOCYTE ACTION (INFLAMMATION) HAS OCCURRED IN CONJUNCTION WITH CONNECTIVE TISSUE TARGETS. PROMINENT AMONG THESE DISEASES ARE PULMONARY EMPHYSEMA, PNEUMONIAS, ADULT RESPIRATORY DISTRESS S ...

IT IS PROPOSED TO DEVELOP A PULSED HYDROGEN FLUORIDE (HF) CHEMICAL LASER SYSTEM THAT IS SPECIFICALLY DESIGNED FOR USE IN CORNEAL MICROSURGERY. LASER PARAMETERS SUCH AS PULSE ENERGY, PULSE DURATION, BEAM QUALITY, AND OUTPUT SPECTRA WILL BE OPTIMIZED FOR APPLICATION IN CORNEAL MICROSURGERY. ISSUES RELATED TO USE IN A MEDICAL ENVIRONMENT, SUCH AS LASER SIZE AND PACKAGING, FUELS AND EXHAUST HANDLING, ...

THE USE OF EXTRATERRESTRIAL SOLAR IRRADIATED SEMICONDUCTOR POWDERS TO PHOTOCATALYTICALLY OXIDIZE ORGANIC TOXICANTS PERSISTENT IN THE SPACE STATION'S POST-TREATED WATER, TO THELEVELS SPECIFIED BY NASA MEDICAL SCIENCES DIVISION, IS PROPOSED. THE TOTAL MINERALIZATION OF SEVERAL CLASSES OF ORGANIC COMPOUNDS BY THE UV IRRADIATION OF UNDOPED, NAKED AND PLATINIZED TIO2 (ANATASE) POWDERS HAS BEEN ABUNDANT ...

THE PURPOSE OF THIS RESEARCH IS PRODUCTION AND TESTING OF A NEEDLE-IMPLANTABLE DEVICE FOR ESTIMATING LONG-TERM TISSUE AVAILABILITY OF THE HORMONE CORTICOSTERONE IN RATS. THIS WORK CONTRIBUTES TO THE LONG-TERM GOAL OF DEVELOPING A SIMILAR DEVICE FOR MEASUREMENT OF THE TISSUE AVAILABILITY OFA BROAD RANGE OF COMPOUNDS IN BOTH RESEARCH AND MEDICAL SETTINGS. THE DEVICE OPERATES ON THE DIFFUSION-SINK PR ...

MOST TYPICAL PROBLEMS IN STRUCTURAL ENGINEERING ARE BEST ANALYZED BY APPROXIMATING AN OBJECT'S GEOMETRY WITH FINITE ELEMENTS. SELECTING AN APPROPRIATE MESHING STRATEGY FOR A GIVEN SOLID REQUIRES KNOWLEDGE ABOUT FINITE ELEMENT THEORY IN GENERAL, AND ABOUT PACKAGE-SPECIFIC DETAILS IN PARTICULAR. THE ADEPT SYSTEM INTEGRATES A TRADITIONAL SOLIDMODELER WITH AN EXPERT SYSTEM EQUIPPED WITH THIS KNOWLEDGE ...

A NEW, INNOVATIVE KIT FOR PARENT SCREENING OF INFANT HEARING(0-24 MONTHS) WILL BE DEVELOPED AND GIVEN TO 300 PARENT PAIRS TO VALIDATE A HOME SCREENING PROGRAM, USING SPECIAL FREQUENCY SOUND-MAKERS. OF THE APPROXIMATELY 4,000,000 BABIES BORN IN THE UNITED STATES EACH YEAR, OVER 1,000,000 DEVELOP HEARING PROBLEMS FROM RECURRENT OTITIS MEDIA DURING THEIR FIRST 24 MONTHS. APPROXIMATELY 8,000 OF THESE ...

A SYSTEM WILL BE DEVELOPED TO EFFICIENTLY AND ACCURATELY MONITOR MOVEMENTS OF THE HUMAN MANDIBLE. THE SYSTEM WILL CONSIST OF A PERSONAL COMPUTER (PC)-BASED DATA ACQUISITION AND ANALYSIS UNIT, A NONRESTRAINING EXTRA-ORAL HARNESS TO WHICH IS ATTACHED A SET OF LIGHT EMITTING DIODES (LEDS), ANDTWO SOLID-STATE DETECTORS TO TRACK THE LEDS IN SPACE. RIGOROUS PHOTOGRAMMETRIC SOFTWARE WILL BE DEVELOPED TO ...

RECENT RESEARCH PERTAINING TO (A) HIGH FREQUENCY AUDIOMETRY UP TO 20 KHZ, (B) TO THE MEASUREMENT OF IN-THE-EAR PRESSURESPRODUCED BY HEARING AIDS AND (C) TO THE RESEARCH AND DIAGNOSTIC APPLICATIONS OF SO-CALLED COCHLEAR DISTORTION PRODUCTS HAVE NECESSITATED ACCURATE KNOWLEDGE OF THE ACOUSTIC WAVE MOTION IN THE EXTERNAL MEATUS. THE ACOUSTIC WAVE MOTION WITHIN THE EXTERNAL MEATUS IS A FUNCTION OF FRE ...

THE PURPOSE OF THIS PROJECT IS TO CONDUCT RESEARCH TO DEVELOP A COMMERCIAL PROGRAM TO INCREASE THE LIKELIHOOD THAT A MINORITY OR DISADVANTAGED EMPLOYEE WILL REMAIN EMPLOYED. OFTEN DUE TO CULTURAL DIFFERENCES AND SKILL LEVELS, EMPLOYMENT OPPORTUNITIES FOR MINORITIES AND DISADVANTAGED PERSONS ARE LIMITED TO MENIAL JOBS PROVIDING MINIMAL SELF-SATISFACTION AND SENSE OF WORTH THUS, HIGH EMPLOYMENT TURN ...

APTEK, AS PRIME CONTRACTOR, IN CONJUNCTION WITH GENERAL ELECTRIC COMPANY AND SRI INTERNATIONAL, AS SUBCONTRACTORS, WILL CONDUCT A STUDY TO IDENTIFY AND INVESTIGATE CANDIDATE OVERLAY MATERIALS VERSUS SYSTEM REQUIREMENTS FOR BOTH ACTIVE AND PASSIVE DECOYS. OVERLAY MATERIALS DEVELOPED BY THE NH&S COMMUNITY WILL BE CONSIDERED AS WELL AS PREVIOUSLY UNEVALUATED CANDIDATES SUCH AS RARE EARTH BORIDES. THE ...