Award Data

DESCRIPTIONprovided by applicantIn this SBIR Phase II projectthe mechanical and fatigue related properties of ultrahigh molecular weight polyethyleneUHMWPEjoint implant materials will be improved by creating a composite material with carbon reinforcementsUHMWPE has long been widely used as wear surfaces in joint implantsand further improvements to its wear resistance have been obtained by cross li ...

DESCRIPTION provided by applicant There are growing demands for D structure determination of nucleic acids and their protein complexes for understanding disease molecule level mechanisms and discovering innovative drugs X ray crystallography is one of the most direct and powerful tools for structure determination of these macromolecules and complexes However the crystallization and phase d ...

DESCRIPTION provided by applicant The AgileLife Patient Transfer System PTS developed and commercially deployed by Next Health LLC is an innovative new device that offers a andquot zero liftandquot solution for patients who are unable to independently transfer to and from bed The AgileLife PTS consists of a fully powered hospital bed a docking station transfer system and a manual wheelcha ...

DESCRIPTION provided by applicant In this Lab to Marketplace proposal we aim to develop the MBF SpineStudio software incorporating the innovative laboratory based NeuronStudio software created at the Mount Sinai School of Medicine Our SpineStudio software will enable automated detection reconstruction and morphological classification of the structural analysis of dendritic spines By creating this ...

DESCRIPTION provided by applicant Adolescents in mental health treatment are at greater risk for HIV and other STIs than their peers due to an earlier age of onset of sex less protected sex more sexual partners and more frequent substance use This greater risk is due to multiple factors including cognitive misperceptions affect dysregulation and less self efficacy The numerous adolescent ...

DESCRIPTION provided by applicant Phase and Phase clinical trials of a new class of redox active pharmaceutical are proposed in high grade glioma WHO grade III and IV This project will test a compound that crosses the blood brain barrier and which prevents hippocampal stem cell loss and white matter degradation following radiation therapy RT The compound also inhibits tumor regrowth f ...

DESCRIPTION provided by applicant Attempts to develop drug treatments for acute lung injury ALI and the acute respiratory distress syndrome ARDS have been marred by unfulfilled expectations Such failures often attributed to the heterogeneous pathophysiology of ALI ARDS and uncertainty about molecular targets of drug action have combined to fuel considerable skepticism about future dru ...

DESCRIPTION provided by applicant Despite medical advances fungal infections still exact a heavy burden on the HIV AIDs population AIDs related fungal infections account for of all AIDs related deaths In the developed world AIDS related fungal infections are most frequently associated with Candida albicans but Aspergillus fumigatus and Cryptococcus neoformans are also common Unfortunat ...

DESCRIPTION provided by applicant Epigenetic modifications of DNA and histones are stable encryption systems essential for life For example the importance of DNA methylation is underscored by the consequences of its mis regulation which include defects in tissue homeostasis chronic disease and accelerated aging thus epigenetics broadly impacts human health The information stored in the di ...

DESCRIPTION provided by applicant The ultimate goal of this project is to market an electromechanical and software system for Blind and Low Vision B LV individuals that will enable interactive creation communication and printing of Braille annotated tactile graphics In school at home and in the workplace virtually everyone needs to be able to produce a wide variety of freehand sketches ...