Award Data

Current methods for stem cell isolation are time-consuming, costly, and labor-intensive, and ill-suited for point of care applications. To overcome these limitations, we propose to develop and demonstrate a high-throughput, non-invasive, microfluidic stem cell analyzer to enable a rapid isolation of high-quality stem cell products from clinically relevant samples. Our technology enables significan ...

In the initial SBIR Phase II, Intelligent Automation, Inc. (IAI) developed a voice-based Tele-PTSD Monitor (TPM) system to remotely screen, monitor, and provide assistance to clinicians in assessing a PTSD patients condition. ListEn is the brain of TPM system. It processes the voice data, extracts different types of salient features, and computes PTSD scores based on state-of-art machine learning ...

Musculoskeletal injury among military personnel is an under-recognized problem where shoulder injuries are significant and result in inflammation and pain from overuse, joint derangement, sprain/stain/rupture, and dislocation. Health hazard assessment is essential to ensure that fielded equipment and occupational duties do not exceed human capabilities over short and long term exposures. Hazard ...

Combat surgery training is an essential mission of the US Armed Forces. Courses such as Emergency War Surgery Course (EWSC) and Advanced Trauma Operative Management (ATOM) have been developed to meet this requirement. However, these courses do not cover all relevant procedures and rely on animals and cadavers which limits their utility. Operative Experience Incorporated will further improve the tr ...

The overall objective of the proposed project is to develop new injury criteria, model based risk assessment methodology, and a software tool to assess neck injury risk from head supported mass (HSM) loading. Based on the foundation of Phase I feasibility studies, the proposed Phase II work will focus on model enhancement, extension and validation, risk assessment, and software integration and tes ...

The vast majority of injuries in recent military conflicts have been inflicted by improvised explosive devices (IEDs) causing brain, extremities and genital-urinary injuries. Advanced computational models of IED blast physics and human body injury biomech

Military personnel must be protected from diseases transmitted by ticks and fleas, including Lyme disease. Effective surveillance of tick and flea vectors is vital to determine the population present, whether they are carrying disease, and whether control campaigns are working. Unfortunately, current surveillance tools are ineffective. In Phase I TDA designed, prototyped, and tested a novel ti ...

TDAs proposes to develop a novel RF heating process for rewarming cryogenically preserved tissues and organs. TDAs approach is to optimize the RF frequency and power, along with the chemical composition, size and morphology of infused nanoparticles so that they heat tissue samples rapidly and uniformly. In this manner, the cryoprotectant solutions pass from the vitrified state to the liquid stat ...

Trauma is the leading cause of death in civilian and military environments and acute hemorrhage contributes to a large portion of these fatalities. Recent experience from Iraq and Afghanistan has demonstrated the crucial role of blood products in the care of critically injured soldiers. Unlike plasma and red blood cells, which can be cold stored for longer time periods, platelets can be safely sto ...

This project will produce an antibacterial nanogel platform to combat multidrug-resistant bacterial infections in wounds. Infections by multidrug-resistant bacteria are increasing at an alarming rate and represents a growing threat to US military medicine and public health. Bacteria such as methicillin-resistant Staphylococcus aureus (MRSA), A. baumannii, P. aeruginosa, E. coli and K. pneumonia ha ...