Award Data

DESCRIPTION (provided by applicant): Among amputation types involving the upper limbs, partial hand is the most prevalent by far and among the most challenging for prosthetists to address well. Sound side overreliance for these amputees gives rise to a high prevalence of contralateral overuse syndrome (COS), a progressive, painful, and debilitating condition. Research shows that prostheses reduce ...

DESCRIPTION (provided by applicant): The proposed effort aims to dramatically enhance the realism of radiation safety training for Emergency Responders, both First Responders, as well as Skilled Support Personnel. The goal is to develop andevaluate realistic dosimetry simulation or Dosimulation tools. These Realistic, Accurate Dosimulation (RAD) tools will be the centerpiece for ...

DESCRIPTION (provided by applicant): In this Phase I SBIR project, TDA Research, Inc. will develop a compact, lightweight portable oxygen concentrator (POC) for medical operations and carry out a breadboard demonstration to produce continuous flow of enriched oxygen (O2) from ambient air. The new POC will weigh less than 10 lbs including the rechargeable batteries that will provide a minimum of 10 ...

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DESCRIPTION: Pulmonary drug delivery is increasingly used for both treatment of lung diseases (such as asthma and chronic obstructive pulmonary disease) and in delivering drugs to the systemic circulation. To reach the desired effectiveness and safety oforally/nasally inhaled drugs, appropriate deposition of drugs on targeted region is essential. Due to complex pharmaceutical and physiological fa ...

DESCRIPTION provided by applicant Castration Resistant Prostate Cancer Castration resistant prostate cancer CRPC directly contributes to patient mortality It is imperative to develop new and effective adjunct therapy to enhance the response of CRPC to hormonal therapy Recently we developed ProFineTM a proprietary formula consisting of bioactive flavonoids enriched in pomegranate fruit and ...

DESCRIPTION provided by applicant DiscoveryBioMed Inc DBM completed recently Phase I SBIR funded goals milestones specific experimental aims and efforts to screen synthetic organic small molecules on immortalized and primary differentiated human adipocyte platforms and to validate the high throughput screening HTS based Drug Discovery output with a Critical Path of bioassays dete ...

IT IS PROPOSED TO PURIFY THE TWO ENVELOPE GLYCOPROTEINS, HN AND F, FROM HUMAN PARAINFLUENZA TYPE 3 (PI3) VIRUS BY AFFINITY CHROMATOGRAPHY USING SPECIFIC MONOCLONAL ANTIBODIES AND TO INCORPORATE THEM INTO LIPID VESICLES. THE EXPERIMENTAL APPROACH INVOLVES IMMOBILIZATION OF SPECIFIC MONOCLONAL ANTIBODY ON A SEPHAROSE 4B MATRIX. PURIFIED VIRUS OR INFECTED CELLS WILL BE USED AS THE SOURCE OF ANTIGENS ...

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DESCRIPTION provided by applicant Improving our understanding of the functional circuitry of the brain has important and manifold implications for our understanding of mental health as well as fields like consciousness and computing In the last decade optical techniques have arisen that allow both recording and control of targeted neurons for brain mapping and many of the best of these tech ...