Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. UHMWPE Composite Material for Joint Implants

    SBC: TDA Research, Inc.            Topic: NIAMS

    DESCRIPTIONprovided by applicantIn this SBIR Phase II projectthe mechanical and fatigue related properties of ultrahigh molecular weight polyethyleneUHMWPEjoint implant materials will be improved by creating a composite material with carbon reinforcementsUHMWPE has long been widely used as wear surfaces in joint implantsand further improvements to its wear resistance have been obtained by cross li ...

    SBIR Phase II 2015 Department of Health and Human Services
  2. Selenium-derivatized New Reagents for Nucleic Acid X-ray Crystallography

    SBC: SENA RESEARCH, INC.            Topic: NIEHS

    DESCRIPTION provided by applicant There are growing demands for D structure determination of nucleic acids and their protein complexes for understanding disease molecule level mechanisms and discovering innovative drugs X ray crystallography is one of the most direct and powerful tools for structure determination of these macromolecules and complexes However the crystallization and phase d ...

    STTR Phase II 2015 Department of Health and Human Services
  3. Automated 3D quantitative analysis of dendritic spines imaged with light microsco

    SBC: MICROBRIGHTFIELD, INC.            Topic: NIMH

    DESCRIPTION provided by applicant In this Lab to Marketplace proposal we aim to develop the MBF SpineStudio software incorporating the innovative laboratory based NeuronStudio software created at the Mount Sinai School of Medicine Our SpineStudio software will enable automated detection reconstruction and morphological classification of the structural analysis of dendritic spines By creating this ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  4. Digital Star HIV Prevention for Youth in Mental Health Treatment

    SBC: VIRTUALLY BETTER INC            Topic: 105

    DESCRIPTION provided by applicant Adolescents in mental health treatment are at greater risk for HIV and other STIs than their peers due to an earlier age of onset of sex less protected sex more sexual partners and more frequent substance use This greater risk is due to multiple factors including cognitive misperceptions affect dysregulation and less self efficacy The numerous adolescent ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  5. BMX-001 as a Therapeutic Agent for Treatment of High-Grade Gliomas

    SBC: BIOMIMETIX JV LLC            Topic: NCI

    DESCRIPTION provided by applicant Phase and Phase clinical trials of a new class of redox active pharmaceutical are proposed in high grade glioma WHO grade III and IV This project will test a compound that crosses the blood brain barrier and which prevents hippocampal stem cell loss and white matter degradation following radiation therapy RT The compound also inhibits tumor regrowth f ...

    SBIR Phase II 2015 Department of Health and Human Services
  6. Mitochondrial DNA repair agents for acute lung injury

    SBC: EXSCIEN CORPORATION            Topic: NHLBI

    DESCRIPTION provided by applicant Attempts to develop drug treatments for acute lung injury ALI and the acute respiratory distress syndrome ARDS have been marred by unfulfilled expectations Such failures often attributed to the heterogeneous pathophysiology of ALI ARDS and uncertainty about molecular targets of drug action have combined to fuel considerable skepticism about future dru ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Single Somatic Cell Epigenetic Models

    SBC: Topogen, Inc            Topic: 200

    DESCRIPTION provided by applicant Epigenetic modifications of DNA and histones are stable encryption systems essential for life For example the importance of DNA methylation is underscored by the consequences of its mis regulation which include defects in tissue homeostasis chronic disease and accelerated aging thus epigenetics broadly impacts human health The information stored in the di ...

    SBIR Phase I 2015 Department of Health and Human Services
  8. Design, Development, and Evaluation of an Interactive Tactile Graphics Printer for the Blind and VisuallyImpaired

    SBC: E.A.S.Y. LLC            Topic: 400

    DESCRIPTION provided by applicant The ultimate goal of this project is to market an electromechanical and software system for Blind and Low Vision B LV individuals that will enable interactive creation communication and printing of Braille annotated tactile graphics In school at home and in the workplace virtually everyone needs to be able to produce a wide variety of freehand sketches ...

    STTR Phase II 2015 Department of Health and Human Services
  9. FASTCOUNT Next generation stereology platform for fast accurate D cell counting

    SBC: MICROBRIGHTFIELD, INC.            Topic: 101

    DESCRIPTION provided by applicant Stereologic cell counting has revolutionized the field of neuroscience over the last years and numerous studies highlighting the impact of stereologic cell counting in basic neuroscience and pharmaceutical and biotechnology research continue to be published A single study however may take months since investigators must decide by visual inspection whethe ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Anatomical Identification at the Microscope using the Brain Navigation System

    SBC: MICROBRIGHTFIELD, INC.            Topic: 101

    DESCRIPTION provided by applicant Microscopic analysis of histologic brain sections yields important information about the organization and composition of the nervous system particularly in modern studies focusing on neuro genomics transcriptomics proteomics and connectomics However identification of distinct brain regions in a section under study with the currently available tools pr ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
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