Award Data

Vascular trauma is the leading cause of death in military environments and hemorrhage is the major preventable cause of mortality among trauma patients. Recent experience from Iraq and Afghanistan has demonstrated improved 24-h and 30-day survival in combat casualties requiring early massive transfusion. Unlike plasma and erythrocytes, which can be cold stored for longer time periods, platelets ca ...

TDA, working with our collaborators, proposes to develop a novel RF heating process for rewarming cryogenically preserved tissues and organs.We have demonstrated high heating rates with the nanoparticles during the Phase I project. In the Phase II project, we will improve our already high heating rate by optimizing the RF heating process, along with the type, size and morphology of the nanoparticl ...

Current methods for stem cell isolation are time-consuming, costly, and labor-intensive, and ill-suited for point of care applications. To overcome these limitations, we propose to develop and demonstrate a high-throughput, non-invasive, microfluidic stem cell analyzer to enable a rapid isolation of high-quality stem cell products from clinically relevant samples. Our technology enables significan ...

Musculoskeletal injury among military personnel is an under-recognized problem where shoulder injuries are significant and result in inflammation and pain from overuse, joint derangement, sprain/stain/rupture, and dislocation. Health hazard assessment is essential to ensure that fielded equipment and occupational duties do not exceed human capabilities over short and long term exposures. Hazard ...

The overall objective of the proposed project is to develop new injury criteria, model based risk assessment methodology, and a software tool to assess neck injury risk from head supported mass (HSM) loading. Based on the foundation of Phase I feasibility studies, the proposed Phase II work will focus on model enhancement, extension and validation, risk assessment, and software integration and tes ...

The vast majority of injuries in recent military conflicts have been inflicted by improvised explosive devices (IEDs) causing brain, extremities and genital-urinary injuries. Advanced computational models of IED blast physics and human body injury biomech

Magnetic resonance imaging (MRI) has become a primary diagnostic tool in scientific research and clinical imaging. Despite the excellent image quality that can be obtained with today’s MRIs, images acquired using different MRI systems and during longitudinal studies are not reproducible, and hence can be difficult, if not impossible, to compare. To address this issue, a standardized test of the ...

Military personnel must be protected from diseases transmitted by ticks and fleas, including Lyme disease. Effective surveillance of tick and flea vectors is vital to determine the population present, whether they are carrying disease, and whether control campaigns are working. Unfortunately, current surveillance tools are ineffective. In Phase I TDA designed, prototyped, and tested a novel ti ...

The advancements in body armor combined with better combat casualty care have greatly increased the survival rate of soldiers suffering battlefield trauma injuries. The increased survivability, however, has resulted in an increase of wounded warriors being sent home with severe injuries that ultimately reduce their quality of life post-treatment, especially those with severe damage to genitourinar ...

Iron deficiency is one of the most common nutritional deficiencies in the United States. Left untreated, iron stores continue to deplete, resulting in iron deficiency anemia. Women undergoing basic military training are particularly susceptible to reduced iron stores. To date, there are no comprehensive point-of-care instruments for accurate determination of iron status. We propose to develop a no ...