Award Data

Recent advances in mammalian artificial chromosome design and engineering offer an alternative to existing methodologies for cellular bioengineering and address unmet needs to bioengineer more complex functionalities into human cells for subsequent commercialization. In this ST13B-001 application we propose to demonstrate utility of a novel chromosome-based gene delivery vehicle that is amenable t ...

The overall objective of the proposed project is to develop new injury criteria, model based risk assessment methodology, and a software tool to assess neck injury risk from head supported mass (HSM) loading. Based on the foundation of Phase I feasibility studies, the proposed Phase II work will focus on model enhancement, extension and validation, risk assessment, and software integration and tes ...

Current methods to discern the differentiation state of stem cells are time-consuming, labor-intensive, costly, invasive, and consequently, ill-suited for clinical applications. To overcome these limitations, we propose to develop a microfluidic stem cell analyzer for accurate, non-invasive identification of the cell differentiation state in conjunction with automated cell sorting at high-throughp ...

Current methods for stem cell isolation are time-consuming, costly, and labor-intensive, and ill-suited for point of care applications. To overcome these limitations, we propose to develop and demonstrate a high-throughput, non-invasive, microfluidic stem cell analyzer to enable a rapid isolation of high-quality stem cell products from clinically relevant samples. Our technology enables significan ...

Associated Proposal has no Abstract

Genome-scale predictable cellular design and engineering of biomanufacturing systems is the overarching a goal of DARPA's Living Foundry thrust and, if realized, will enable rapid engineering of living biosystems for a broad range of applications in biotechnology and pharmacology. However, constructing living cells with designed genome is not fully automated and is severely limited by inhere ...

Advances in biodegradable materials have allowed the development of a variety of resorbable medical devices that do no need to be removed at the end of their service because they degrade within the body into not toxic by-products. However, devices that contain electronic components are still nearly all non-degradable because of the lack of biodegradable conducting and semiconducting materials. T ...

ColdQuanta proposes the development of compact electric field sensors that operate from 1 to 1000 GHz and feature absolute accuracy better than 1%. These devices will utilize highly excited Rydberg atoms that are exceptionally sensitive to RF, microwave, and millimeter radiation. Featuring sensitivities of a few uV/cm, the accuracy of these devices will be at least one order of magnitude better t ...

Many geospatial technologies and modeling techniques exist, especially for 3-D visualization of correlated layers of data. A gap remains in integrating the unstructured world of voice, chat, and free-form text communications to the more structured world

CFDRC proposes to develop new acoustic metamaterials, more specifically Locally Resonant Sonic Materials (LRSM), to be used in passive Hearing Protection Devices (HPD). LRSM derive their unique properties from resonators contained within each unit cell. Sound attenuation of finite size of LRSM is determined by the interaction of an incident elastic pulse with the resonators within the unit cells. ...