Award Data

Military personnel must be protected from diseases transmitted by ticks and fleas, including Lyme disease. Effective surveillance of tick and flea vectors is vital to determine the population present, whether they are carrying disease, and whether control campaigns are working. Unfortunately, current surveillance tools are ineffective. In Phase I TDA designed, prototyped, and tested a novel ti ...

TDAs proposes to develop a novel RF heating process for rewarming cryogenically preserved tissues and organs. TDAs approach is to optimize the RF frequency and power, along with the chemical composition, size and morphology of infused nanoparticles so that they heat tissue samples rapidly and uniformly. In this manner, the cryoprotectant solutions pass from the vitrified state to the liquid stat ...

We will evaluate a novel warming method, developed by our collaborator John Bischof, that promises solution of one of the remaining barriers for banking of large organs and vascularized composite tissues. The method involves radiofrequency and magnetic nanoparticles to obtain rapid uniform electromagnetic rewarming of biological materials instead of warming from the outer boundary using convection ...

The long term goal of the proposed research is to develop improved methods for cryopreservation of complex tissues at extreme low temperature. An innovative approach is taken in the proposed line of research, where synthetic ice modulators (SIMs) are combined with established cryoprotective agent (CPA) cocktails to create more favorable conditions for cryopreservation in a process known as vitrifi ...

In this Phase I effort, FIRST RF will develop and evaluate concepts for advanced Surface Search Phased Array radar systems that will be integrated on Naval Special Warfare Combatant-Craft. A phased array system allows for dynamic beam steering with graceful degradation and eliminates the need for mechanical pointing of the antenna aperture. The FIRST RF SSPA radar system will detect, locate, track ...

nanoRETE is a developing a nanoparticle-based biosensor technology platform that has the ability for real-time detection of pathogens. Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis (Mtb) that primarily affects the lungs. In Phase I research, nanoRETE demonstrated proof-of-concept of an electrochemical nano-bead biosensor for measuring plasma cytokine and chemokine concentrati ...

Civilian and military organizations throughout the world perform surveillance to combat vector-borne disease. Of particular concern to the U.S. military are mosquito genera Anopheles, Aedes and Culex, which are important vectors for malaria, dengue and West Nile virus respectively, and sand fly genera Phlebotomus and Lutzomyia, both vectors for leishmaniasis. The trap most commonly used for by U.S ...

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