Award Data

Project Summary Cytoprotective and restorative treatments for acute ischemic stroke (AIS) is a major unmet medical need. The current standard of care for stroke patients is centered on recanalization efforts to restore cerebral perfusion through the administration of tissue plasminogen activator (tPA) or mechanical thrombectomy. However, despite a recent extension of recanalization treatment windo ...

This project aims to develop NeuroManager™, an innovative neuroinformatics platform for advanced parsing, storing, aggregating, analyzing and sharing of complex neuroscience image data. A core technology that we will develop in NeuroManager will be Image Content Analysis for Retrieval Using Semantics (ICARUS), a novel, intelligent neuroimage curation system that will enable image retrieval based ...

An Integrated CT-based Image-Guided Neurosurgical System In this SBIR Phase IIb proposal Xoran intends to commercialize a compact and affordable, yet highly- functional, system to provide real time image updates and navigation guidance in support of minimally invasive cranial and spinal neurosurgical procedures. The effort builds on previously developed compact and portable flat-panel Computed Tom ...

Project Summary/Abstract There has been a shift to greater use of neadjuvant chemotherapy (NACT) in the clinical management of cancer. Often used in breast cancer to provide systemic treatment for possible or apparent metastatic disease, NACT also reduces the primary tumor size and facilitates breast conservation. Quantitative magnetic resonance imaging (qMRI) is an effective diagnostic for monito ...

Glycans and glycoconjugates are widespread in nature and play pivotal roles in cell-cell recognition, cell differentiation, and immunological responses. Most glycans and glycosylation reactions require nucleotide sugars as their essential building blocks. Therefore, the commercial availability of nucleotide sugars will determine future opportunities for carbohydrate-based innovations, just as the ...

Abstract Yearly influenza epidemics strike millions of people, causing up to 500,000 deaths. Fatality caused by most seasonal influenza viruses is andlt;0.03%, but with significant mortality in the young and the elderly populations. When a new pathogenic influenza strain enters the population, a pandemic could kill tens of millions of people with a negative economic impact estimated to be over 150 ...

ABSTRACTExtracorporeal membrane oxygenation (ECMO) use continues to increase as a supportive measure for cardio-respiratory failure. Pediatric patients with severe, acute left ventricular (LV) systolic dysfunction are often supported with venoarterial (VA) ECMO as a short-term bridge to recovery, transplant or a ventricular assist device (VAD). ECMO provides temporary gas exchange and increased ca ...

Sweat contains biomarkers that give an indication of human cognitive levels. In this SBIR project TDA Research is developing a modular sweat sensor patch that has the capability to not only carry out real-time monitoring of select biomarkers, but also to

Currently, deployed medics are required to transport, maintain and be resupplied with liquid-based medications and materials that are heavy, expensive to transport, perishable and may require refrigeration. Many medications and materials are or will soon

PROJECT SUMMARY The β-hemoglobinopathies are prevalent genetic blood diseases with few treatment options. It is estimate that 7% of the worldandapos;s population carries an abnormal hemoglobin gene with 400,000 infants born annually with a severe life threatening hemoglobinopathy. Drug mediated induction of normal, but developmentally silenced, fetal hemoglobin (HbF) expression reduces anemia and ...