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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A compact, modular two-photon fiber-coupled microscope for in vivo all-optical electrophysiology

    SBC: INTELLIGENT IMAGING INNOVATIONS, INC.            Topic: 101

    Good methods to interrogateand ideally perturbneural systems at the network level have been elusive until recentlyThe advent of biochemical breakthroughsnamely neuronally targeted genetically encoded calcium reporterssuch as GCaMPand light activated channelssuch as channelrhodopsinhave enabledall opticalelectrophysiology where experiments can be conducted that involve simultaneousor closely sequen ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. A Computer Tool for Aiding in Accurate Assessment of Indeterminate Lung Nodules

    SBC: International Intelligent Informatics Solution Laboratory LLC            Topic: 101

    DESCRIPTION provided by applicant Primarily due to the lack of physical symptoms in the early stage lung cancer remains the leading cause of cancer deaths in the United States and worldwide Although high resolution computed tomography CT has been proved to be a sensitive non invasive modality for visualizing small lung nodules which could be the early manifestation of lung cancer a consi ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Active Disposable Cap for Endoscope Tip Stabilization and Complete Visualization and Dissection of Serrated Sessile Polyps

    SBC: ACTUATED MEDICAL, INC.            Topic: 300

    The SBIR Fast-track develops, tests, and commercializes the ‘Active Disposable Cap for Endoscope (ACE) Tip Stabilization and Complete Visualization and Dissection of Serrated Sessile Polyps.’ The disposable system includes a distal-connecting cap, allowing a clinician to manipulate tissue and perform targeted aspiration during complex polypectomies using proximal controls, without occupying th ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Active Variable-Stiffness Prosthetic Foot

    SBC: INTELLIGENT PROSTHETIC SYSTEMS, LLC            Topic: NICHD

    DESCRIPTION provided by applicant The long term goal of this project is to develop prosthetic foot technology that can function differently for different activities Although current prostheses can be very effective for particular tasks e g walking running or standing an amputee must choose a single prosthesis to achieve reasonably good performance across all daily activities This resul ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Actuated Low-Force Biopsy Tool for Versatile Bone Lesion Access with Less Trauma

    SBC: ACTUATED MEDICAL, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): In this Phase II SBIR, Actuated Medical, Inc. will complete the development of the Actuated Low-Force Biopsy Tool for Versatile Bone Lesion Access with Less Trauma. Public Health Problem: Percutaneous bone biopsy is performed to obtain tissue for specific diagnosis of bone lesions identified through imaging or clinical evaluation. A major disadvantage of the ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  6. Addressing Opioid Use Disorder with an External Multimodal Neuromodulation Device: Development and Clinical Evaluation of DuoTherm for Opioid-Sparing in Acute and Chronic Low Back Pain.

    SBC: MMJ Labs, LLC            Topic: NIDA

    Project Summary The goal of this project is to develop a multimodal neuromodulatory opioid sparing device for low back paindemonstrate effective pain reliefthen evaluate opioid reduction for patients with acute or chronic back pain presenting for treatmentPain and opioid use disorderOUDare intricately relateddependence begins for up towith medications prescribed for paineither directly or through ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. A Diarylheptanoid Scaffold to Treat Taopathies

    SBC: ALS BIOPHARMA, LLC            Topic: NIA

    DESCRIPTION: We identified the Myrica cerifera (Southern Bayberry) extract using a systematic screen as a potent reducer of the structural protein tau, which accumulates in a group of diseases called the tauopathies . The most prevalent tauopathy is Alzheimer's disease, for which there is renewed interest in the identification of tau- based therapeutic approaches to treat this devastating d ...

    STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  8. A Dietary Supplement As Adjunct Therapy In Castration-Resistant Prostate Cancer

    SBC: MetCure Therapeutics LLC            Topic: 102

    DESCRIPTION provided by applicant Castration Resistant Prostate Cancer Castration resistant prostate cancer CRPC directly contributes to patient mortality It is imperative to develop new and effective adjunct therapy to enhance the response of CRPC to hormonal therapy Recently we developed ProFineTM a proprietary formula consisting of bioactive flavonoids enriched in pomegranate fruit and ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. A disposable assay for the monitoring of heart failure in the home setting

    SBC: ACCEL DIAGNOSTICS, LLC            Topic: NHLBI

    DESCRIPTION provided by applicant The objective of this proposed SBIR Phase is to complete the clinical validation of a novel blood assay pScreen BNP tm for the monitoring and management of heart failure HF in the home and Point of Care POC settings pScreen BNP tm has several unique features It is fully disposable single use and does not requires bench top or hand held devices h ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Advanced GST Proteomics for Early Stage Organ-Specific Toxicity Screening. Phase

    SBC: OXFORD BIOMEDICAL RESEARCH, INC.            Topic: NIEHS

    DESCRIPTION: Biomarkers currently employed for the detection of organ toxicity are often not sensitive enough to detect the early stages of acute organ damage, i.e. at a stage when reducing or eliminating exposure to a toxin could prevent progression of organ damage or a disease process, nor do they adequately discriminate damage to one organ system vs. another. For example, the level of aminotra ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
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