Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. A Dietary Supplement As Adjunct Therapy In Castration-Resistant Prostate Cancer

    SBC: MetCure Therapeutics LLC            Topic: 102

    DESCRIPTION provided by applicant Castration Resistant Prostate Cancer Castration resistant prostate cancer CRPC directly contributes to patient mortality It is imperative to develop new and effective adjunct therapy to enhance the response of CRPC to hormonal therapy Recently we developed ProFineTM a proprietary formula consisting of bioactive flavonoids enriched in pomegranate fruit and ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. A Holographic Module for Multiphoton Microscopes in Neuroscience

    SBC: Boulder Nonlinear Systems, Inc.            Topic: 101

    DESCRIPTION provided by applicant Improving our understanding of the functional circuitry of the brain has important and manifold implications for our understanding of mental health as well as fields like consciousness and computing In the last decade optical techniques have arisen that allow both recording and control of targeted neurons for brain mapping and many of the best of these tech ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  3. A next-generation spatial light modulator for mapping of neural networks

    SBC: Boulder Nonlinear Systems, Inc.            Topic: NIBIB

    DESCRIPTION provided by applicant Improving our understanding of the fundamental circuitry and dynamics of the brain has far reaching implications for a wide range of fields including mental health computing and the philosophy of the mind To this end one of the critical questions currently facing neuroscientists lies in how brain states and behaviors arise from the activity of ensembles of ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. A compact, modular two-photon fiber-coupled microscope for in vivo all-optical electrophysiology

    SBC: INTELLIGENT IMAGING INNOVATIONS, INC.            Topic: 101

    Good methods to interrogateand ideally perturbneural systems at the network level have been elusive until recentlyThe advent of biochemical breakthroughsnamely neuronally targeted genetically encoded calcium reporterssuch as GCaMPand light activated channelssuch as channelrhodopsinhave enabledall opticalelectrophysiology where experiments can be conducted that involve simultaneousor closely sequen ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Active Variable-Stiffness Prosthetic Foot

    SBC: INTELLIGENT PROSTHETIC SYSTEMS, LLC            Topic: NICHD

    DESCRIPTION provided by applicant The long term goal of this project is to develop prosthetic foot technology that can function differently for different activities Although current prostheses can be very effective for particular tasks e g walking running or standing an amputee must choose a single prosthesis to achieve reasonably good performance across all daily activities This resul ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Addressing Opioid Use Disorder with an External Multimodal Neuromodulation Device: Development and Clinical Evaluation of DuoTherm for Opioid-Sparing in Acute and Chronic Low Back Pain.

    SBC: MMJ Labs, LLC            Topic: NIDA

    Project Summary The goal of this project is to develop a multimodal neuromodulatory opioid sparing device for low back paindemonstrate effective pain reliefthen evaluate opioid reduction for patients with acute or chronic back pain presenting for treatmentPain and opioid use disorderOUDare intricately relateddependence begins for up towith medications prescribed for paineither directly or through ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Advanced therapeutic for Parkinson's Disease

    SBC: INHIBIKASE THERAPEUTICS            Topic: 999

    Parkinsonandapos s DiseasePDis a progressive neurodegenerative disorder that affectsmillion patient in the U Sannually andtomillion people worldwidePD is characterized by disorders of movementwhich are caused by the progressive loss of dopamine neurons in the substantia nigra pars compactaSNpcand autonomic dysfunctionanxietydepressionsleep disorders and cognitive impairment that are due to the deg ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. A fast, scalable, cost-effective, single-stranded library protocol for cell-free DNA

    SBC: Claret Bioscience LLC            Topic: 102

    Project Summary Liquid biopsy is a potentially powerfulnon invasive approach for detectingclassifying and monitoring tumors by capturing cell free DNA molecules found circulating in blood and other bodily fluidsAny next generation sequencingNGSbased approach requires an efficient protocol for converting cell free DNA into a sequencing libraryNearly all currently available NGS library preparation m ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. A Microscale Platform for Augmentation of Cell Transduction (MPACT) to Enhance Ex Vivo Gene Transfer

    SBC: EXPRESSION THERAPEUTICS LLC            Topic: NHLBI

    PROJECT SUMMARY ABSTRACT Recent advances in clinical gene therapy highlight the need for improved lentiviral vectorLVand adenoassociated viralAAVvector manufacture and utilization efficiencies for enhanced therapeutics outcomesExpression Therapeutics in collaboration with Emory University are developing a microfluidicFluidictechnology based solution that overcomes the mass transport and diffusion ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. An Automated Platform for High-throughput Network Electrophysiology

    SBC: Axion Biosystems, Inc.            Topic: 102

    DESCRIPTION provided by applicant In response to the program announcement for Phase IIb proposals for complex in vitro brain and behavior tools PA this proposed study automates all aspects of in vitro Microelectrode Array MEA technology to deliver the first ever high throughput MEA based screening system This development will not only enable rapid advancements in the study of basi ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
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