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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Scientific Merit and Feasibility of Fructokinase Inhibition for Obesity

    SBC: Colorado Research Partners LLC            Topic: NIDDK

    Our goal is to develop a firstin class therapeutic agent that directly blocks the metabolism of fructosea key component in sugarIntake of sugarsucroseand high fructose corn syrupHFCSinduces metabolic syndrome and diabetes in laboratory animals and are strongly associated with obesity and diabetes in humansBoth sucrose and HFCS contain fructosewhich stimulates food intake by inducing leptin resista ...

    STTR Phase II 2017 Department of Health and Human Services
  2. Therapeutic TRPA Mechanism Based Treatment of Chemotherapeutic Induced Neuropathic Pain

    SBC: ALGOMEDIX, INC.            Topic: 102

    Abstract Cancer patients treated with many widely used chemotherapeutic agents including paclitaxel PAC and oxaliplatin OXA frequently develop chemotherapy induced peripheral neuropathy CIPN that may lead to dose reduction dosing schedule changes and termination of treatment In some patients acute peripheral neuropathy PN can transition into chronic PN lasting well beyond termination ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Rational drug selection for Alzheimer s disease using Indicator Cell Assay Platform iCAP

    SBC: PreCyte Inc            Topic: NIA

    Project Summary We are developing a novel tool for disease diagnosis called the indicator cell assay platform iCAP that uses standardized cultured cells as biosensors to detect disease status of patients from blood or cerebral spinal fluid CSF samples Here we propose to establish proof of concept for applying the assay to drug discovery by initiating development of the iCAP for drug selectio ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a protein drug for pancreatic cancer treatment

    SBC: ProDa BioTech L.L.C.            Topic: NCI

    Abstract Pancreatic cancers are devastating diseases with five year survival rate less than Currently there is no effective treatment for advanced disease One major barrier to efficacy of anti tumor therapeutics is the dense desmoplastic stromal response Evidence suggests that cancer associated pancreatic stellate cells CAPaSC produce the stromal collagen The ECM laid down by CAPaSC is c ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Membrane-based vaccine with checkpoint blockade for triple negative breast cancer

    SBC: METACLIPSE THERAPEUTICS CORPORATION            Topic: 102

    The worldwide incidence of breast cancer ismillionTriple negative breast cancersTNBCaccount forof total breast cancer casesworldwideAnnuallyovernew cases of TNBC are diagnosed in the US aloneThe treatment options for TNBC patients are limitedTriple negative breast cancerTNBCincludes breast cancers that lack estrogen receptorprogesterone receptorand HERproteinsLack of known targets and patient to p ...

    SBIR Phase II 2017 Department of Health and Human Services
  6. Clinical Study of an Extended Patency Dialysis Access Graft

    SBC: HEALIONICS CORPORATION            Topic: 300

    Clinical Study of an Extended Patency Dialysis Access Graft PROJECT SUMMARY Objective The goals of this PAR Clinical Studies Fast Track SBIR proposal are to move a novel hemodialysis access graft design to k submission and upon k clearance conduct a patient clinical study to demonstrate improved performance compared to current synthetic grafts which have high rate of clot ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A Nanopatterned Interdigitated Electrode Array Device for Anti migratory Cancer Drug Screening

    SBC: NANOSURFACE BIOMEDICAL, INC.            Topic: 102

    PROJECT SUMMARY As the cancer drug industry suffers from the lowest success rate in developing cancer cure drugs cell migration assessment assays that evaluate the transition of cells from a benign to a metastatic phenotype have gained more attention Given the fact that metastatic cancer cells are substantially harder to eradicate than those that are benign migratory propensity is now understoo ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Patient-centered leukemia diagnostic and monitoring using the HemoLink-MD

    SBC: Tasso, Inc            Topic: NCI

    Project Summary There is an urgent unmet need for simplified and improved blood testing systems that can be utilized outside of centralized clinical settingsBlood cancers are a major health problem in the United Statesrepresenting overof all new cancersAcute myeloid leukemiaAMLis a particularly fast evolving form of cancer with low rates of survivalFollow initial therapy treatmentsAML patients mus ...

    SBIR Phase I 2017 Department of Health and Human Services
  9. Monoclonal lamprey VLR antibodies specific for mucin type O linked glycan core structures

    SBC: Novab, Inc.            Topic: 300

    PROJECT SUMMARY We will develop and commercialize to the research community a new class of glycan specific binding reagents that incorporate the recognition function of variable lymphocyte receptors VLRs the antigen receptors of the adaptive immune system of jawless vertebrates lamprey and hagfish Such reagents are essential to detecting localizing quantifying and establishing biological ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. RealConsent: A web-based program to reduce college women's risk of sexual violence by targeting alcohol use, communication and consent, and building supportive networks.

    SBC: Behavioral Science Technologies, LLC            Topic: 400

    Sexual violenceSVexperienced by women on college campuses is a serious public health problem that has garnered a national responseCampus climate surveys show that approximately one in five college women experience sexual violenceFederal regulations now mandate implementation of educational prevention programs for new students of institutions of higher educationIHEsBest practices for sexual violenc ...

    STTR Phase II 2017 Department of Health and Human Services

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