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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. An Automated Early Motor Development Risk Screener from Observational Video Recordings of Infants and Toddlers

    SBC: BSolutions Inc            Topic: NICHD

    Motor development plays a pivotal role in an infant s overall development and has a cascading effect on socialcognitivememoryand language abilityThese functions can be compromised when motor development is disruptedmotor disruption is associated with generalized developmental delaysEarly screening and identification of delays can allow early interventions with the goal of not just improving motor ...

    SBIR Phase II 2018 Department of Health and Human Services
  2. Detection and Staging of Liver Fibrosis by Precise MRI (pMRI)

    SBC: INLIGHTA BIOSCIENCES L.L.C.            Topic: NIAAA

    Abstract Chronic liver injury due to alcoholmetabolic dysfunctionviral hepatitisor autoimmune disease results in liver inflammation and fibrosisLiver fibrosis will progress to cirrhosis which is estimated to affectof the world s populationThe major clinical consequences of cirrhosis are liver failure and hepatocellular carcinomaHCCboth of which increase the risk of deathAlcoholic liver diseaseALDi ...

    STTR Phase II 2018 Department of Health and Human Services
  3. Optimization and Validation of an Indicator Cell Assay for Blood-Based Diagnosis of Alzheimer's Disease

    SBC: PreCyte Inc            Topic: NIA

    Project SummaryPreCyte is developing the Indicator Cell Assay PlatformiCAPas a broadly applicable and inexpensive blood based assay that can be used for the early detection of diseasedisease stage stratificationprognosis and predicting response to therapy for a variety of diseasesThe iCAP uses culturedstandardized cells as biosensorscapitalizing on the ability of cells to respond to disease signal ...

    SBIR Phase II 2018 Department of Health and Human Services
  4. Large-aperture Electrically Tunable Lenses with 40 Microsecond Hysteresis-free response for Remote Focusing

    SBC: Boulder Nonlinear Systems, Inc.            Topic: 101

    PROJECT SUMMARY This Phase II Lab to Marketplace proposal aims to commercialize a new remote focusing technique that can change the focus of a microscope by as much asm in less thansorders of magnitude faster than other discrete focus change techniquesOur initial market is neuroscience imagingwhere the ability of researchers to step between focal planes at the millisecond timescale of neuronal cir ...

    SBIR Phase II 2018 Department of Health and Human Services
  5. Early Detection of Ovarian Cancer Using Uterine Lavage and Duplex Sequencing

    SBC: Twinstrand Biosciences, Inc.            Topic: 102

    Early Detection of Ovarian Cancer Using Uterine Lavage and Duplex Sequencing Nearly a quarter of a million new cases of ovarian cancer are identified every year worldwide and the majority of these woman will die from their diseaseWhen detected earlysurgical cure rates exceedbut currently most cases are detected at an advanced stage when the cancer has already disseminatedAs suchour most pressing p ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. CAMS Relational Agent System (CAMS-RAS) for Suicide Prevention

    SBC: EVIDENCE-BASED PRACTICE INSTITUTE, LLC            Topic: 104

    PROJECT ABSTRACTOverpeople die annually by suicide in the United StatesUSmaking suicide theth leading cause of death overall and the second leading cause of death among thoseIn additionmillion adults contemplate suicide annuallyand one million will make a suicide attemptFromtothe rate of ED visits for suicidal ideation among adults increased byon average annuallyWhile millions are devoted annually ...

    SBIR Phase II 2018 Department of Health and Human Services
  7. High-specificity affinity reagents for the detection of glycan sialylation

    SBC: GLYCOSENSORS AND DIAGNOSTICS, LLC            Topic: 300

    PROJECT SUMMARY Glycans have several distinct properties that make them potential disease biomarkersFirstlytheir location on cell surfaces makes them the first point of contact for cellular interactionsand thus they are crucial in the control of normal metabolic processesSecondlycell surface molecules are strategically exposed for surveillance by the immune systemwhere they may serve as immune rec ...

    SBIR Phase II 2018 Department of Health and Human Services
  8. Development of a protein drug for pancreatic cancer treatment

    SBC: ProDa BioTech L.L.C.            Topic: NCI

    Abstract Pancreatic cancers are devastating diseases with five year survival rate less thanCurrentlythere is no effective treatment for advanced diseaseOne major barrier to efficacy of anti tumor therapeutics is the dense desmoplastic stromal responseEvidence suggests that cancer associated pancreatic stellate cellsCAPaSCproduce the stromal collagenThe ECM laid down by CAPaSC is considered to be o ...

    STTR Phase II 2018 Department of Health and Human Services
  9. Kinetic Phenotype Discovery Informatics for Neurological Diseases

    SBC: DRVISION TECHNOLOGIES LLC            Topic: 101

    Project Summary Neurological disorders significantly outnumber diseases in other therapeutic areas and are growing in incidence faster than any other disease classes However the pharmaceutical industry has been unsuccessful in coming up with effective drugs A big factor in these failures has been a lack of adequate model systems for fundamental disease understanding affecting both diagnosis and ...

    SBIR Phase I 2016 Department of Health and Human Services
  10. Kinetic Phenotype Discovery Informatics for Neurological Diseases

    SBC: DRVISION TECHNOLOGIES LLC            Topic: 101

    Project Summary Neurological disorders significantly outnumber diseases in other therapeutic areas and are growing in incidence faster than any other disease classesHoweverthe pharmaceutical industry has been unsuccessful in coming up with effective drugsA big factor in these failures has been a lack of adequate model systems for fundamental disease understanding affecting both diagnosis and treat ...

    SBIR Phase II 2017 Department of Health and Human Services

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