Award Data

DESCRIPTIONprovided by applicantIn this SBIR Phase II projectthe mechanical and fatigue related properties of ultrahigh molecular weight polyethyleneUHMWPEjoint implant materials will be improved by creating a composite material with carbon reinforcementsUHMWPE has long been widely used as wear surfaces in joint implantsand further improvements to its wear resistance have been obtained by cross li ...

DESCRIPTION provided by applicant There are growing demands for D structure determination of nucleic acids and their protein complexes for understanding disease molecule level mechanisms and discovering innovative drugs X ray crystallography is one of the most direct and powerful tools for structure determination of these macromolecules and complexes However the crystallization and phase d ...

A key challenge toward future directed energy systems is the development of power and thermal management technologies needed to support the laser systems, particularly pump diodes.I2C Solutions and the University of Colorado have developed a Thermal Ground Plane (TGP) technology that interfaces with doide laser bars in order to spread heat and transport it to the laser cooling loop.During Phase II ...

DESCRIPTION provided by applicant Adolescents in mental health treatment are at greater risk for HIV and other STIs than their peers due to an earlier age of onset of sex less protected sex more sexual partners and more frequent substance use This greater risk is due to multiple factors including cognitive misperceptions affect dysregulation and less self efficacy The numerous adolescent ...

Theoretical computing speeds have increased dramatically in the last decade with chip advances, including Graphics Processor Units (GPUs).In practice, however, these gains have not been realized, largely due to the accompanying high development costs due to the need for multiple code bases to take advantage of the various chips and their variants.The proposed project addresses these issues from bo ...

DESCRIPTION provided by applicant Phase and Phase clinical trials of a new class of redox active pharmaceutical are proposed in high grade glioma WHO grade III and IV This project will test a compound that crosses the blood brain barrier and which prevents hippocampal stem cell loss and white matter degradation following radiation therapy RT The compound also inhibits tumor regrowth f ...

ColdQuanta proposes the development, fabrication, testing and demonstration of a free-space microshutter based on MEMS technology. The microshutter head will provide extinction ratios exceeding 70 dB and shutter transition times below 10 us, and it will be smaller than any other free space shutter technology currently available. The proposed shutter leverages prior experience with the successful d ...

DESCRIPTION provided by applicant Epigenetic modifications of DNA and histones are stable encryption systems essential for life For example the importance of DNA methylation is underscored by the consequences of its mis regulation which include defects in tissue homeostasis chronic disease and accelerated aging thus epigenetics broadly impacts human health The information stored in the di ...

We present the design of a small, portable, microwave cold atomic clock that meets the frequency stability requirement of

The team proposes to leverage their expertise to develop an anti-submarine warfare (ASW) variant of Area-Is Air-Launched, Tube-Integrated Unmanned System (ALTIUS). ALTIUS, meaning higher in Latin, represents a paradigm shift in the performance of small, tube-launched unmanned aircraft. Core features and capabilities of the ALTIUS-ASW will include: A highly efficient, lightweight, composite airfram ...