Award Data

The scope of this work includes design, analysis, manufacturing, integration, and test of the GO1 hypersonic flight test platform. The Contractor shall complete design of the system, qualify the system for flight through ground testing, and validate the f

Abstract Subarachnoid hemorrhageSAHremains a serious source of neurological morbiditywith approximatelycases reported in the US each yearDespite advances in treating the initial and subsequent bleedspost surgical clipping of the aneurysm is associated with a significant risk of delayed cerebral ischemiaDCIThese events typically occur within the firstdays after aneurysmal rupture and DCI remains th ...

Parkinson s DiseasePDis a progressive neurodegenerative disorder that affectsmillion patient in the U Sannually andtomillion people worldwidePD is characterized by disorders of movementwhich are caused by the progressive loss of dopamine neurons in the substantia nigra pars compactaSNpcand autonomic dysfunctionanxietydepressionsleep disorders and cognitive impairment that are due to the degenerati ...

Project Summary AbstractThe overall aim of this project is to further develop a novel gemcitabine ibandronate conjugate alone and or as part of a combination therapy for the treatment of osteosarcoma and associated metastasesThe conjugate consists of chemically linked anticancer antimetabolite Gemcitabine and the bone homing bisphosphonate IbandronateThe novel conjugate directly addresses the limi ...

Abstract The liver is the most common organ for metastasis of various cancersincluding pancreaticovariancolorectalgastric cancers and melanomaUveal melanoma metastasizes inof patients and upon metastasis targets the liver inof these casesThe most common primary malignant liver cancer worldwide is hepatocellular carcinomaHCCThe use of blind liver biopsy as a diagnostic tool for liver cancer has man ...

Inhibikase Therapeutics is a clinical stagebiopharmaceutical company that has developed a hosttargeted mechanism of action to treat AIDS related and drug induced progressive multifocal leukoencephalopathyPMLPML is a demyelinating disease of the central nervous system and was rarely seen clinically until the era of the HIV epidemic began in the midsDuring the height of the epidemicthe rate of PML o ...

Abstract The worldwide incidence of breast cancer ismillionTriple negative breast cancersTNBCaccount forof total breast cancer casesworldwideAnnuallyovernew cases of TNBC are diagnosed in the US aloneThe treatment options for TNBC patients are limitedTriple negative breast cancerTNBCincludes breast cancers that lack estrogen receptorprogesterone receptorand HERproteinsLack of known targets and pat ...

Sophisticated radar antennas such as an active electronically scanned aperture (AESA) are used to support acquisition and tracking in multiple modes over wide bandwidths, monopulse tracking, and Sense and Avoid RADAR (SAA) for UAV applications. These multi-function radar systems are small but require a considerable amount of power, which in turn produces a significant amount of heat. For these sys ...

Summary In a variety of diseases and conditions when oral feeding is impossibleenteral feeding through percutaneous gastrostomyPGis necessary to provide long term nutrition for adult and pediatric patientsIt is estimated that overthousand feeding tubes are placed in pediatric patients in the US annuallyHoweverthese patients frequently experience complications associated with PG tube placementLate ...

The ability to accurately machine nickel-based alloys and other hard materials is critical to the manufacture of Army weapons such as mortar tubes, and electrochemical machining (ECM) is often the best, or only, option. The primary drawback of ECM is designing ECM tools. Tool design is extremely complex because the shape of the machined workpiece depends on tool shape, electrolyte and material ele ...