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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Optimizing Direct Delivery of Nucleic Acid Therapeutics

    SBC: FHC, INC.            Topic: NIMH

    Project Summary While nucleic acid therapeutics have shown promise in rodent and nonhuman primate models of CNS diseasesall double blind clinical trials to date have failedOne likely explanation for this failure is poor therapeutic distribution in targeted brain regionsFor examplepost mortem studies of patients with Parkinsonandapos s Disease receiving intraparenchymal injections of AAV NTN demons ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Automated Real-Time Trauma Resuscitation Communication System for Clinical Decision Support

    SBC: Lifeboard Medical            Topic: NLM

    PROJECT SUMMARY Despite rapid transport to appropriate facilitiesmany trauma patients needlessly die in the first hour of careTrauma is the leading cause of death for Americans under the age ofand greatest cause of potential life years lost before the age ofexceeding that of either cancer or heart diseaseUp toof traumatic deaths may be preventableIt is estimated that miscommunication is the leadin ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Single-cell Phosphoprotein Assay to Evaluate Brain Tumor Therapeutic Resistance

    SBC: ISOPLEXIS CORPORATION            Topic: 102

    Although signal transduction inhibitors occasionally offer clinical benefit for cancer patientssignal flux emanating from oncogenes is often distributed through multiple pathwayspotentially underlying the resistance which causes failure of most such inhibitorsMeasuring signal flux through multiple pathwaysin response to signal transduction inhibitorsmay help uncover network interactions that contr ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Robust Predictor of Colon Cancer Risk

    SBC: Morgan and Mendel Genomics, Inc.            Topic: 102

    Summary At leastpeople in the United States are at high risk for Lynch syndromebased on inheritance of a genetic mutation in the mismatch repairMMRor double strand breakDSBrepair pathwayMore than half of them are unaware of their riskbecause their family history is uninformative or unknownGenetic testing is important for identifying mutations in this pathwaybut in a large number of cases no mutati ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. A Quality Control Program for Quantitative MRI DataAcquisition and Analysis in Multi-site Clinical Trials

    SBC: CALIBERMRI INC            Topic: 101

    Project Summary Abstract There has been a shift to greater use of neadjuvant chemotherapyNACTin the clinical management of cancerOften used in breast cancer to provide systemic treatment for possible or apparent metastatic diseaseNACT also reduces the primary tumor size and facilitates breast conservationQuantitative magnetic resonance imagingqMRIis an effective diagnostic for monitoring tumor reg ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Development of an a MC1R selective companion diagnostic imaging probe

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    The melanocortinreceptorMC Ris over expressed on uveal and cutaneous melanoma cellsbut notin healthy normal tissuesWe have developed a proprietary ligandMTIthat binds to MC R inmelanoma cells with high affinity and specificityThrough our SBIR Phase I contractwedemonstrated that MC R targetedAc DOTA MTIlacks of overt toxicity at single doses thatproduce significant efficacy against uveal and cutane ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Proprietary biologic treatment to heal skin wounds

    SBC: Allander Biotechnologies            Topic: NIDCR

    SUMMARY Chronic skin wounds associated with various diseasese gdiabetesand aberrant healing from acute woundinge ghypertrophic scarringare a major health care burdenThis health burden increases in aging populationsThe cost to treat these conditions exceeds $billion annuallyCurrentlyREGRANEXa cream containing a biologic based on human PDGFPlatelet Derived Growth Factoris the only FDAFood and Drug A ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a Clinical Screening Platform for Type 1 Diabetes

    SBC: Op-T-Mune, Inc            Topic: NIDDK

    AbstractA major shortfall in clinical care for diabetes is a rapid and accurate screen for progression to diseaseCurrent criteria involve HLA haplotypeand the presence of auto antibodiesAAGenome wide associated studiesGWASrevealed only immune associated genes including HLA as T D predictorsThe ability to differentiate from other diseases was very limitedPre typediabetesp T Dis now being identified ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. PINPOINT: Gaming technology to engage adolescent sickle cell patients in precision pain Phase I

    SBC: KLEIN BUENDEL, INC.            Topic: 102

    Sickle cell diseaseSCDis the most common inherited blood disorder in the U Sand disproportionately affects African Americans and HispanicsApproximatelyU Schildren are born with SCD annuallySCD results from abnormal hemoglobin and causes red blood cellsRBCsto become misshapedsickle shapedSickled cells can block the flow of blood in small arteries causing tissue and organ damage and other lifethreat ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Smartphone Help for DWI Offenders and Their Families: A B-SMART App

    SBC: KLEIN BUENDEL, INC.            Topic: 450

    Driving while intoxicatedDWIremains a substantial and preventable source of morbidity and mortality in the United StatesA variety of sanctions and interventions have been attempted to reduce DWI in the U Sincluding enhanced DWI enforcement effortsstricter drunk driving lawsresponsible alcohol beverage service trainingand alcohol treatmentThe Ignition Interlock DeviceIIDwhich requires a driver to b ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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