Award Data

The objective of the Ballistic Missile Defense System (BMDS) is todetect, identify, and track targets using sensor observations, andengage the lethal objects using interceptors.To achieve the desired level of effectiveness, the system mustdistinguish between the lethal and non-lethal objects.Object identification is performed by a discrimination systemthat relies on a tracking system to associate ...

DESCRIPTION provided by applicant Prostheses reduce the incidence of contralateral overuse syndrome in upper limb amputees by encouraging balanced bimanual limb usage Benefits include reduced pain and muscular atrophy increased productivity and self reliance improved self image a sense of well being and increased social acceptance Body powered prostheses are used extensively in the Uni ...

ABSTRACT Laparotomy patients are plagued with ventral hernias occurring and recurring in up to 30% of cases. Hernia occurrence and recurrence is caused by anchor point failure of both permanent and degradable mesh (i.e. suture, tacks, and screws cheese-wire through mesh and tissue, resulting in mesh migration and/or contraction). Simply, hernias occur or recur where mesh is not adequately anchored ...

DESCRIPTION (provided by applicant): Millions of children in the U.S. are at risk for learning to read well despite major advances in our understanding of the causes and cures for poor reading. In this Fast- Track proposal we propose to address this significant need and opportunity with a computer-based reading program that combines the power of one-on-one tutoring with the benefits of self-assess ...

PROJECT SUMMARY End Stage Renal DiseaseESRDis a complex disease that involves total and permanent kidney failure that affects moreindividuals in the United States aloneHemodialysis is a life sustaining therapy for patients suffering from renal failure that requires that blood be withdrawn and cycled through a dialysis machine that performs the function of the failed kidneysThis process must be rep ...

PROJECT SUMMARY End Stage Renal Disease (ESRD) affects more 750,000 individuals in the United States alone. Hemodialysis (HD) is a life-sustaining therapy for patients suffering from renal failure that requires blood to be withdrawn and cycled through a dialysis machine. This process requires repeated needle punctures and the consequent needle access to a surgically created vascular shunt. These s ...

PROJECT SUMMARYNucleosomesNucsare the repeating units of chromatinmade up of DNA wrapped around a histone octamerChanges in chromatin structurefunction can dramatically impact downstream gene expression and cellular physiologydriving oncogenic reprogramming and cancer progressionThis epigenetic regulation of chromatin is controlled by two major modificationshistone post translational modifications ...

DESCRIPTION (provided by applicant): The effort under this proposal is to prepare for and perform a large clinical study using in-vivo confocal microscopy to validate the results of a smaller, recently published study of the efficacy of this technology for diagnosis of melanoma. The main goal of this Type 2 Phase II Competing Continuation SBIR Proposal is to obtain data for submission to the FDA a ...

PROJECT SUMMARY Irreproducibility of biomedical and preclinical research is responsible for wasting 50% of the entire research budget and accounts for billions of wasted dollars. Issues with authenticity of key resources, such as cell lines, form a major contributor to this problem. An alarming increase in cell authenticity issues has prompted the NIH and some journals to take action by requiring ...

DESCRIPTION (provided by applicant): Conventional body-powered assistive appliances intended to help children having upper limb deficiencies have proven inadequate for some activities, most notably play. The critical component in these systems that contributes grasp functionality, called a prehensor or terminal device, must strike a balance between functionality for activities children wish to ac ...