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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. The Assessment of Smart Phone Everyday Tasks (ASSET): A new IADL test for early AD

    SBC: RIP ROAD, INC.            Topic: NIA

    Project SummaryImpairment in instrumental activities of daily living (IADL) is a hallmark of Alzheimer’s disease (AD) dementia and a major source of patient and caregiver burden. Similarly to cognitive changes in AD, subtle difficulties in IADL may begin even before the stage of amnestic mild cognitive impairment (MCI). Recently, greater emphasis has been placed on preclinical AD, which consists ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. A single dose anti-scarring therapeutic for the cornea

    SBC: DUB BIOLOGICS, INC            Topic: NEI

    Abstract DUB Biologics is developing a therapeutic for the prevention and treatment of corneal scarring through knockdown of a novel target that has been shown to be central to the fibrotic response leading to corneal opacification. Corneal opacification severely impairs the vision of 4.2 million people around the world, 5.1% of the total blind population. Monocular scarring is far more common, af ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  3. miRNA-Nanotechnology as a novel regenerative therapy for lymphangioleiomyomatosis

    SBC: BIOSPUTNIK LLC            Topic: 172

    ABSTRACT Lymphangioleiomyomatosis (LAM) is a Tuberous sclerosis-related disorder. Both occur due to an inherited or sporadic mutation in either the TSC1 or TSC2 gene, which function as negative regulators of the mTOR pathway. Uncontrolled mTORC1 activity leads to the neoplastic proliferation of abnormal smooth muscle cells (LAM cells) in the lungs, progressive shortness of breath, recurrent pneumo ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Engineered Biotherapeutic Agent for Treatment of Post-Traumatic Osteoarthritis

    SBC: Provizigen LLC            Topic: NIAMS

    PROJECT SUMMARY/ABSTRACT Post-traumatic osteoarthritis (PTOA) is a degenerative disease of cartilage brought on by traumatic injury to the articular joints. Acute joint injury is followed by severe joint pain and inflammation. This results in much more rapid degeneration of cartilage than in other forms of osteoarthritis, due to the joint instability caused by trauma as well as the increase in pro ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. The Language Equity and Accessibility Performance (LEAP) Initiative: Addressing disparities through a paradigm shift in language services operations

    SBC: Transcendent International, LLC            Topic: 102

    PROJECT SUMMARY Patients with limited English proficiency (LEP) continue to experience a range of health disparities compared to English-proficient patients. Addressing persistent gaps in language services requires a paradigm shift in which health systems evaluate and track their compliance with relevant regulations, implement staff training, and carefully craft and communicate exhaustive language ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Live spike sorting for multichannel and high-channel recordings

    SBC: POPNEURON LLC            Topic: 106

    Project Summary: The goal of this project is to create two prototypes of a novel live spike sorting system which can be used by investigators to spike sort streams of neural data recorded by multi-channel, high channel and ultra-high channel probes. In most in-vivo extracellular recording conditions, an electrode can pick up neural spikes from several nearby neurons resulting in so-called “multi ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Developing an integrated pipeline for routine generation of orthogonal GPCR-targeting nanobodies

    SBC: VITAN-BIOTECH LLC            Topic: 300

    Project SummaryA broad range of neurological indications, including schizophrenia, pain, Parkinson's and Alzheimer's diseases, and autism have been linked to G-protein coupled receptor proteins (GPCRs), making them attractive targets for therapy. Understanding GPCR dysfunction is essential for effective therapeutic development. However, deciphering the functions of GPCRs remains a daunting task in ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Mission Empower

    SBC: ROCK BY ROCK LLC            Topic: NIGMS

    Project Summary: Mission Empower: Health According to the Society of Public Health Education, only 7.5% of K-5 schools nationally provide sufficient health education (Society for Public Health Education, 2017). IDM and game-based learning strategies have the potential to help close this gap but, to date, most public health solutions have not been scalable (Zamboni, et al 2019). Too often IDM and h ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. IND-enabling toxicology studies to reach IND approval for a proprietary biologic to treat oral mucositis in cancer patients

    SBC: Allander Biotechnologies            Topic: NIDCR

    Summary Oral mucositis, a severe oral ulceration, is a common toxic effect of radio- or chemoradio-therapy (RT or CRT) and a limiting factor to using the optimal dose of radiation for effective cancer treatment. Intensity modulated RT (IMRT) and stereotactic Body RT (SBRT) spare more normal tissues and lessen chronic side effects, but not oral mucosa in head and neck cancer patients. To date, Pali ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Advanced Pediatric Airway Trainer for Enhanced Clinical Education in Pediatric Critical Care

    SBC: TDA RESEARCH, INC.            Topic: NICHD

    Project Summary/Abstract Clinical training aids such as surgical mannequins and procedural trainers are important tools for teaching proper technique to physicians and first responders. However, the majority of these training tools were developed for adult anatomies. Pediatric patients are often more challenging to treat, but few resources exist for advanced simulation in pediatric critical care e ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
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