Award Data

PROJECT SUMMARY End Stage Renal DiseaseESRDis a complex disease that involves total and permanent kidney failure that affects moreindividuals in the United States aloneHemodialysis is a life sustaining therapy for patients suffering from renal failure that requires that blood be withdrawn and cycled through a dialysis machine that performs the function of the failed kidneysThis process must be rep ...

Project SummaryAbstract There is growing need of high throughput analytical platforms to study interactions of cell surface glycans and glycan binding proteinsWe propose here to develop aKglycan array to facilitate functional glycomics researchTwo hurdles for development of a comprehensive glycan array arelack of a sensitive glycan array substrate enabling multivalent binding eventsandlack of a co ...

Abstract OsteoarthritisOAremains a significant source of significant pain and disabilityaffecting overmillion adults with an economic burden of over $billion per year to the USJoint replacement is a well established procedurebut its finite life span makes this treatment unacceptable for younger or more active individualswho often require additional revision surgeries as they ageBoth complicated re ...

ABSTRACT Significance Electronic prescribing is now widely adopted by US healthcare systems but clinical functionality of e prescribing falls short in the realm of pediatrics Medication prescribing is intrinsically more complex for pediatric patients due to weight based dosing the lack of widely adopted medication formulation recipes inconsistent off label ...

PROJECT SUMMARY Autism Spectrum Disorder ASD describes a collection of neurodevelopmental abnormalities of varying severity that have been estimated to impact more than of Americans mostly males ASD can negatively impact one s ability to communicate and navigate social interactions In its most severe forms ASD also can lead to self destructive repetitive behaviors that require affli ...

Abstract Osteoarthritis OA is a degenerative joint disease that affects an estimated million adults in the United States and results in an economic burden of over $ billion per year Although the burden of OA is immense current non surgical treatments are only palliative and no disease modifying OA drugs DMOADs presently exist to address the problem This lack of success in identifying ...

ABSTRACT The objectives of the Kidney Precision Medicine Project KPMP project are to create a kidney tissue atlas define disease subgroups and identify critical cells pathways and targets for novel therapies by obtaining and evaluating kidney biopsies from participants with acute kidney injury AKI and chronic kidney disease CKD As part of this effort there is a need for new technologie ...

Abstract This SBIR phase proposal is to demonstrate the pre clinical safety and efficacy of a novel carbon nanostructure based X ray computer tomography CT contrast agent CA for imaging and monitoring in patients with renal failure or at risk of contrast induced nephropathy CIN Routine contrast enhanced CT scans relays crucial information about diseases and injuries thus aiding the clini ...

ABSTRACT A High School Program for Preventing Prescription Drug Abuse This Fast Track SBIR proposal is designed to address the critical need for an effective primary prevention approach for prescription drug abuse PDA an urgent public health crisis in the United States Deaths from prescription drug overdoses have more than tripled in the past years and the abuse of prescription opioids has ...

Abstract AsystBio LLC proposes to market a molecular tool kit called AML MutationCounter to count somatic mutations in genes that contribute to the development of acute myeloid leukemia AML We have developed a set of reagents and computer programs for application of next generation sequencing to count AML gene mutations The tool kit is versatile and can be used with either of the two major DNA ...