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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. "Modulation of Immune Checkpoints by Self Deliverable RNAi for Adoptive Cell Transfer"

    SBC: ADVANCED RNA TECHNOLOGIES LLC            Topic: 102

    Two of the most promising approaches to cancer immunotherapy are immune checkpoint blockade by monoclonal antibodies and the adoptive transfer of immune cells The recent successes in treating melanoma with anti PD and anti CTLA antibodies as well as the extremely successful application of T cells engineered to express the CAR receptor targeting CD to treat B cell lymphomas initiated a waterfal ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. 3D living neural networks

    SBC: MEADOWLARK OPTICS, INC.            Topic: 101

    DESCRIPTION provided by applicant Mental disease including schizophrenia depression and autism spectrum disorders are still poorly understood although it is clear that they mostly represent cortical disorders The cortex is the primary site of higher mental functions yet despite extensive research there is still no unified theory of how the cortex works This is partly due to the fact that ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. A Biomimetic Prehensile Digit for Upper-Limb Amputees

    SBC: Invisible Hand Enterprises, LLC            Topic: NICHD

    DESCRIPTION provided by applicant Prostheses reduce the incidence of contralateral overuse syndrome in upper limb amputees by encouraging balanced bimanual limb usage Benefits include reduced pain and muscular atrophy increased productivity and self reliance improved self image a sense of well being and increased social acceptance Body powered prostheses are used extensively in the Uni ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. A D osteoarthritis model targeting patient populations with high risk genetic polymorphisms

    SBC: Cytex Therapeutics, Inc.            Topic: NIAMS

    Abstract Osteoarthritis OA is a degenerative joint disease that affects an estimated million adults in the United States and results in an economic burden of over $ billion per year Although the burden of OA is immense current non surgical treatments are only palliative and no disease modifying OA drugs DMOADs presently exist to address the problem This lack of success in identifying ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. A Data driven Approach to Improve Nursing Workflow and Patient centered Care

    SBC: Transcendent International, LLC            Topic: 102

    DESCRIPTION provided by applicant Patient centered care recognizes patientsandapos desires opinions and preferences as equal in importance to those of healthcare professionals and emphasizes the need to educate and empower patients to play an active role in their care The achievement of patient centered care is associated with increased patient and provider satisfaction improved health ou ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  6. A diagnostic for maternal autoAb to Caspr to predict increased risk of autism spectrum disorder in children

    SBC: Spark2Flame, Inc            Topic: NICHD

    PROJECT SUMMARY Autism Spectrum Disorder ASD describes a collection of neurodevelopmental abnormalities of varying severity that have been estimated to impact more than of Americans mostly males ASD can negatively impact one s ability to communicate and navigate social interactions In its most severe forms ASD also can lead to self destructive repetitive behaviors that require affli ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A High School Program for Preventing Prescription Drug Abuse

    SBC: NATIONAL HEALTH PROMOTION ASSOCIATES, INC            Topic: NIDA

    ABSTRACT A High School Program for Preventing Prescription Drug Abuse This Fast Track SBIR proposal is designed to address the critical need for an effective primary prevention approach for prescription drug abuse PDA an urgent public health crisis in the United States Deaths from prescription drug overdoses have more than tripled in the past years and the abuse of prescription opioids has ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A Holographic Module for Multiphoton Microscopes in Neuroscience

    SBC: Boulder Nonlinear Systems, Inc.            Topic: 101

    DESCRIPTION provided by applicant Improving our understanding of the functional circuitry of the brain has important and manifold implications for our understanding of mental health as well as fields like consciousness and computing In the last decade optical techniques have arisen that allow both recording and control of targeted neurons for brain mapping and many of the best of these tech ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  9. A Multi-channel Web Platform to Provide Holistic Care to Underserved Consumers

    SBC: Transcendent International, LLC            Topic: NIMHD

    DESCRIPTION provided by applicant Significant obstacles exist in care delivery that prevents meaningful utilization of mental health services by consumers who experience health disparities Specifically individuals facing isolation due to linguistic literacy or cultural bariers often face challenges in procuring mental health care These challenges are in part due to the medical and mental systemsan ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  10. A neurokinin receptor agonist to treat underactive bladder in the elderly

    SBC: Dignify Therapeutics LLC            Topic: NIA

    PROJECT SUMMARY ABSTRACT Underactive bladder UAB is a condition wherein a bladder contraction of reduced strength and or duration results in prolonged bladder emptying and or a failure to achieve complete bladder emptying within a normal time span The overarching hypothesis of this application is that in the absence of physiologically induced bladder contractions pharmacologically induced co ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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