Award Data

DESCRIPTION provided by applicant Ocular graft versus host disease O GVHD is a particularly severe and debilitating complication of allogeneic hematopoietic stem cell transplantation HSCT O GVHD develops in of patients with chronic GVHD Currently Restasis cyclosporine A is the only FDA approved prescription topical medication to treat O GVHD In Restasis had sales o ...

DESCRIPTION provided by applicant There are growing demands for D structure determination of nucleic acids and their protein complexes for understanding disease molecule level mechanisms and discovering innovative drugs X ray crystallography is one of the most direct and powerful tools for structure determination of these macromolecules and complexes However the crystallization and phase d ...

DESCRIPTION provided by applicant Thousands of individuals seek refuge in the United States to escape atrocities of war and torture in their country of origin An overwhelming majority of these individuals continue to struggle with Chronic Traumatic Stress CTS the persistence of prior traumatic events e g re experiencing past trauma coupled with daily post migration stressors e g pove ...

DESCRIPTION provided by applicant KDH Research and Communication KDHRC with the American College of Rheumatology ACR will develop LLPI Latinas con Lupus Promotoras con Informaci n Latinas with Lupus Promotoras with Information a culturally competent unique online professional development course course to improve the ability of promotoras de salud promotoras to raise awareness ...

DESCRIPTION provided by applicant This SBIR project seeks to develop novel technologies for the manipulation and labeling of the interior of living eukaryotic cells for research diagnostic and eventually therapeutic purposes Cell penetrating peptides offer the tantalizing prospect of delivering a broad palette of user defined protein cargoes through the plasma membranes of eukaryotic cells C ...

DESCRIPTION provided by applicant The overall goal of this project is to test a meal replacement beverage that will ultimately preserve muscle loss during calorie restriction weight loss CRWL in obese older individuals We previously developed a meal replacement rich with a proprietary blend of essential amino acids TMR that was more than three times as effective as whey protein in stimulat ...

DESCRIPTION provided by applicant Chronically ill children are an underserved under represented and disadvantaged population with regards to education In addition to the childandapos s medical illness they are also at high risk for psychological problems One of the most common psychological problem areas is educational difficulties or academic and learning problems due to regular school abs ...

DESCRIPTION provided by applicant Stereologic cell counting has revolutionized the field of neuroscience over the last years and numerous studies highlighting the impact of stereologic cell counting in basic neuroscience and pharmaceutical and biotechnology research continue to be published A single study however may take months since investigators must decide by visual inspection whethe ...

DESCRIPTION provided by applicant The long term goal of this project is to develop and test a nutritional product that will improve physical function in individuals with heart failure H in the geriatric population Our approach to nutritional therapy NT focuses on increasing skeletal muscle strength improving vascular reactivity and optimizing regulation of energy substrate metabolism All ...

DESCRIPTION provided by applicant The ultimate goal of this project is to market an electromechanical and software system for Blind and Low Vision B LV individuals that will enable interactive creation communication and printing of Braille annotated tactile graphics In school at home and in the workplace virtually everyone needs to be able to produce a wide variety of freehand sketches ...