Award Data

DESCRIPTION provided by applicant In this Lab to Marketplace proposal we aim to develop the MBF SpineStudio software incorporating the innovative laboratory based NeuronStudio software created at the Mount Sinai School of Medicine Our SpineStudio software will enable automated detection reconstruction and morphological classification of the structural analysis of dendritic spines By creating this ...

DESCRIPTION provided by applicant Adolescents in mental health treatment are at greater risk for HIV and other STIs than their peers due to an earlier age of onset of sex less protected sex more sexual partners and more frequent substance use This greater risk is due to multiple factors including cognitive misperceptions affect dysregulation and less self efficacy The numerous adolescent ...

DESCRIPTION provided by applicant Stereologic cell counting has revolutionized the field of neuroscience over the last years and numerous studies highlighting the impact of stereologic cell counting in basic neuroscience and pharmaceutical and biotechnology research continue to be published A single study however may take months since investigators must decide by visual inspection whethe ...

DESCRIPTION provided by applicant Microscopic analysis of histologic brain sections yields important information about the organization and composition of the nervous system particularly in modern studies focusing on neuro genomics transcriptomics proteomics and connectomics However identification of distinct brain regions in a section under study with the currently available tools pr ...

DESCRIPTION provided by applicant The proposed project Directed Lineage Immunizations for Eliciting Broadly Neutralizing Antibody tests the directed lineage D L approach to HIV vaccination using clade C immunogens With a D L vaccine a series of progressively evolved Env immunogens are used to drive development of a broadly neutralizing antibody bnAb response which is important because ...

DESCRIPTION provided by applicant Thousands of individuals seek refuge in the United States to escape atrocities of war and torture in their country of origin An overwhelming majority of these individuals continue to struggle with Chronic Traumatic Stress CTS the persistence of prior traumatic events e g re experiencing past trauma coupled with daily post migration stressors e g pove ...

DESCRIPTION provided by applicant We present a new family of contrast agents based on targeting the maltodextrin transporter termed maltodextrin based imaging probes MDPs which are designed to image infections associated with implanted medical devices by fluorescent imaging The chemical structure of an MDP is composed of maltodextrins conjugated to a fluorescent dye MDPs have the potentia ...

DESCRIPTION provided by applicant The NIH Blueprint for Neuroscience Research identified a need for novel products that engage students in learning neuroscience In Phase I IS D tested the feasibility of Nurbits a videogame in which students apply neuroscience principles to solve puzzles and make music The research team determined that Nurbits was effective in engaging students teachers wer ...

DESCRIPTION provided by applicant The surgeonandapos s choice of method for closing incisions is becoming increasingly problematic Metal surgical staples are unacceptable for Minimally Invasive Surgery MIS procedures currently percent of surgeries in the US and are out of favor in traditional procedures due to complications and the cost of staple removal Due to the time required for ma ...

DESCRIPTION provided by applicant The overall goal of this project is to test a meal replacement beverage that will ultimately preserve muscle loss during calorie restriction weight loss CRWL in obese older individuals We previously developed a meal replacement rich with a proprietary blend of essential amino acids TMR that was more than three times as effective as whey protein in stimulat ...