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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Selenium-derivatized New Reagents for Nucleic Acid X-ray Crystallography

    SBC: SENA RESEARCH, INC.            Topic: NIEHS

    DESCRIPTION provided by applicant There are growing demands for D structure determination of nucleic acids and their protein complexes for understanding disease molecule level mechanisms and discovering innovative drugs X ray crystallography is one of the most direct and powerful tools for structure determination of these macromolecules and complexes However the crystallization and phase d ...

    STTR Phase II 2015 Department of Health and Human Services
  2. Infant Screening of Early Communication Risk: The CISS, Phase II

    SBC: PAUL H BROOKES PUBLISHING CO., INC.            Topic: Y

    DESCRIPTIONprovided by applicantEffective early intervention depends on reliable screening of risk for communication impairments as soon as possibleEstablished infant communication risk factors include poor attentiongesturessocial connectednessexploratory playand speechAlthough these risk factors can be detected bymosand reliably predict later language and social disordersattempts to detect simila ...

    STTR Phase II 2015 Department of Health and Human Services
  3. Innovative Unified Damage Mechanisms-Based Model to Predict Remaining Useful Life for Rotorcraft Structures

    SBC: TECHNICAL DATA ANALYSIS, INC.            Topic: N14AT002

    Recent studies by the PI and the Co-PI of this STTR effort have shown that aluminum alloys and stainless steel in Low Cycle Fatigue (LCF) fail upon reaching a critical entropy; claimed to be an intrinsic material property. The critical entropy has been used as damage metric for prediction of remaining useful life (RUL). Also, similar entropic concept has previously been applied to LCF of composite ...

    STTR Phase II 2015 Department of DefenseNavy
  4. Coupled Multi-physics Analysis and Design Optimization of nozzles (COMANDO)

    SBC: Intelligent Automation, Inc.            Topic: N14AT005

    The US Navy faces daunting energy challenges that will further increase in severity, given the ever-increasing global demand for energy, diminishing energy supplies and demand for enhanced environmental stewardship. Additionally, noise is an important issue for the Navy due to the adverse effect it has on personnel and communities around naval air bases and training sites. Military combat aircraft ...

    STTR Phase II 2015 Department of DefenseNavy
  5. Selective inhibitors of Heme Transporters as Antiparasitic Agents

    SBC: Rakta Therapeutics, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Neglected Tropical Diseases NTD which include helminthiasis and leishmaniasis are a group of thirteen parasitic and bacterial infections that affect over billion people Although these are devastating diseases of global concern their neglected status relative to other health concerns has resulted in a limited arsenal of therapeutic compounds for their ...

    STTR Phase I 2015 Department of Health and Human Services
  6. A Percutaneous Ultrasound-Guided Catheter for Organ and Vascular Access

    SBC: PERCEPTIVE NAVIGATION LLC            Topic: NHLBI

    DESCRIPTION provided by applicant Safe and reliable access to major blood vessels and internal organs will be beneficial to patients with cardiovascular disease and cancer An interventional catheter with forward viewing ultrasound imaging capability will be developed to enable image guided access to blood vessels and internal organs Phase experiments demonstrate feasibility of building a hi ...

    STTR Phase II 2015 Department of Health and Human Services
  7. Microfluidic Processing of Leukocytes for Molecular Diagnostic Testing

    SBC: GPB SCIENTIFIC, LLC            Topic: 102

    DESCRIPTION provided by applicant The goal of this Phase II project is to optimize and validate a microfluidic chip based process that automates and shortens the labeling washing and collecting of human blood leukocytes WBCs for flow cytometric analysis of clinically important cell surface and intracellular markers Multi parameter flow cytometry is an increasingly powerful and widely used t ...

    STTR Phase II 2015 Department of Health and Human Services
  8. Acousto-Optic Tunable Filter-Based Polarimetric Spectral Sensor With Progressive Algorithm For Material Analysis and Mapping

    SBC: BRIMROSE TECHNOLOGY CORPORATION            Topic: T801

    One of the strategic goals of NASA's Planetary Science Mission is to advance scientific knowledge of the origin and history of the solar system, the potential for life elsewhere. The current STTR addresses this strategic goal. The proto-type AOTF-based SWIR spectropolarimetric imaging system developed in Phase I (which will be further optimized and integrated with optimal algorithm/software in Pha ...

    STTR Phase II 2015 National Aeronautics and Space Administration
  9. Enhanced multiphoton microscopy through spatial light modulation

    SBC: Boulder Nonlinear Systems, Inc.            Topic: 102

    DESCRIPTION provided by applicant Nonlinear optical microscopy techniques and particularly multiphoton fluorescence microscopy have become popular tools for visualizing the three dimensional cellular architecture residing hundreds of microns and up to one millimeter deep in living organisms This is particularly valuable in neurobiology where multiphoton techniques have become widely used fo ...

    STTR Phase II 2015 Department of Health and Human Services
  10. Physics-Based Modeling Tools for Life Prediction and Durability Assessment of Advanced Materials

    SBC: ELDER RESEARCH INC            Topic: T1202

    The technical objectives of this program are: (1) to develop a set of physics-based modeling tools to predict the initiation of hot corrosion and to address pit and fatigue crack formation in Ni-based alloys subjected to corrosive environments, (2) to implement this set of physics-based modeling tools into the DARWIN probabilistic life-prediction code, and (3) to demonstrate corrosion fatigue crac ...

    STTR Phase II 2015 National Aeronautics and Space Administration

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