Award Data

A 22-KDA PROTEIN THAT HAS POTENT ACTIVITY AGAINST A NUMBER OF CLINICALLY IMPORTANT HUMAN PATHOGENS HAS BEEN ISOLATED FROM MAIZE SEEDS. IN ADDITION, THIS PROTEIN, NAMED ZEAMATIN, HAS THE UNIQUE ABILITY TO SYNERGIZE WITH KNOWN ANTIFUNGAL DRUGS, DECREASING THE DOSE REQUIRED FOR FUNGAL CELL KILLING WHILE INCREASING THE SPECTRUM OF ACTIVITY. AS A PRELUDE TO IN VIVO TESTING, IT IS PLANNED TO DETERMINE T ...

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THE LONG-TERM OBJECTIVE OF THIS PROJECT IS A BETTER UNDERSTANDING OF INFANT AND TODDLER MOTOR DEVELOPMENT. SPECIFIC AIMS INCLUDE THE DEVELOPMENT AND VALIDATION OF NEW STRATEGIES FOR ANALYZING MOTOR BEHAVIOR WITH EMPHASIS ON QUALITY OF MOVEMENT. QUALITY OF MOVEMENT WILL BE OPERATIONALIZED AS: (1) VARIATIONS WITHIN A POSITION, (2) TRANSITIONS WITHIN A POSITION, (3) COMPLEX COMBINATIONS OF SINGLE MOT ...

OVER 1.5 MILLION PEOPLE HAVE HEART ATTACKS IN THE UNITED STATES EVERY YEAR AND OVER HALF A MILLION DIE AS A RESULT. RAPID AND ACCURATE DIAGNOSIS AFTER THE ONSET OF SYMPTOMS IS IMPORTANT NOT ONLY TO INSTITUTE PROPER THERAPY BUT ALSO TO RULE OUT MYOCARDIAL INFARCTION (MI). BECAUSE ELECTROCARDIOGRAMS CAN BE MISLEADING, A NUMBER OF LABORATORYENZYME TESTS HAVE BEEN USED TO DIAGNOSE MI, BUT THESE PROCED ...

STC TECHNOLOGY GROUP, INC., WAS FORMED TO ADDRESS THE HUMAN DEXTERITY PROBLEM. A BIMANUAL TELEMICROROBOTICS TEST BED, FEATURING HIGH-PRECISION PARALLEL ROBOTIC MANIPULATORS, HAS BEEN DESIGNED WITH A MAJORITY OF THE COMPONENTS IN PLACE. THIS PROJECT ADDRESSES A SUBSET OF THE OVERALL SYSTEM: THE 3-DOF FINE MANIPULATOR. IN DESIGNING THE 3-DOF FINE MANIPULATOR SYSTEM FOR THE TEST BED, IT BECAME APPARE ...

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A SOFT X-RAY LASER AT PRINCETON UNIVERSITY (18.2 NM WAVELENGTH, 10-30 NSEC PULSES) CAN PRODUCE IMAGES OF LIVE CELLS IN WATER ON RESIST. IN COLLABORATION WITH PRINCETON UNIVERSITY, PRINCETON X-RAY LASER, INC., IS DEVELOPING LASERS WITH SHORTER WAVELENGTHS. THERE ARE REALISTIC PROSPECTS FOR OBTAINING LASER ACTION BELOW 10 NM, DOWN TO 1 NM. VIABLE BIOMEDICAL USE REQUIRES METHODS TO RETRIEVE INFORMATI ...

CHEMEX PHARMACEUTICALS, INC.'S, NORDIHYDROGUAIARETIC ACID (CHX 100) IS A POTENT ANTIOXIDANT ALSO POSSESSING ANTIPROLIFERATIVE, ANTITUMOR, AND LIPOXYGENASE INHIBITION ACTIVITIES. THESE ACTIONS, ESPECIALLY ITS ANTIOXIDANT AND LIPOXYGENASE INHIBITORY ACTIVITIES, SUGGEST THAT CHX 100 MAY REDUCE THE DELETERIOUS EFFECTS OF ACUTE ULTRAVIOLET LIGHT (UVL) EXPOSURE ON THE SKIN, AS THESE EFFECTS MAY BE ASSOC ...

THE ULTIMATE GOAL OF PROJECT TRANSITION IS TO BRING ABOUT INCREASED EARLY INTERVENTION IN AND PREVENTION OF ABUSIVE ALCOHOL USE PATTERNS AMONG DIVORCED AND SEPARATED WOMEN WHO ARE KNOWN TO BE AT RISK OF SUBSTANCE ABUSE BY DEVELOPING LOW-COST, NONSTIGMATIZED EDUCATIONAL MATERIALS THAT CAN BE DISTRIBUTED BY THE NATURAL NETWORK OF SERVICE PROVIDERS WHO REGULARLY COME INTO CONTACT WITH THIS POPULATION ...

HUMAN T-CELL LEUKEMIA VIRUS TYPE II (HTLV-II) IS CONSIDERED TO BE AN ETIOLOGIC AGENT OF HAIRY CELL LEUKEMIA, AND ITS PREVALENCE IS INCREASING IN THE BLOOD SUPPLY. THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO PRODUCE AN IMMUNOLOGICAL ASSAY TO STUDY ITS PREVALENCE IN THE BLOOD SUPPLY. THIS PHASE I RESEARCH SPECIFICALLY AIMS TO DEVELOP A RECOMBINANT DNA SYSTEM TO PRODUCE A PORTION OF THE ENVELOPE PR ...